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Technical Library

Technical Library

Featured Items from our Technical Library

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LC-MS/MS Analysis of Paraquat and Diquat without Ion-Pairing Reagents

LC-MS/MS analysis of paraquat and diquat herbicides is an important tool for protecting human and environmental health. However, the ion pairing reagents that are commonly used to improve retention, resolution, and peak shape have a negative impact on sensitivity and can contaminate the system necessitating frequent cleaning. The LC-MS/MS analysis of paraquat and diquat presented here provides complete separation and good peak response for both target analytes in a fast, 7-minute gradient run without the use of troublesome ion pairing reagents.
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Featured Application: Extractable Semivolatile Organic Compounds on Rxi-5Sil MS

Sample throughput for semivolatiles analysis can be significantly increased by employing split injection instead of splitless injection. Split injection allows more samples to be analyzed per shift because it utilizes a higher initial GC oven temperature and faster oven cycle time. Pairing a robust Rxi-5Sil MS column with split injection ensures fast, accurate results for analyzing semivolatiles under procedures such as Method 8270.
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Featured Application: Volatile Amines on Rtx-Volatile Amine

Restek’s Rtx-Volatile Amine column is specifically designed for GC analysis of volatile amines in challenging matrices. The stable bonded phase is highly retentive and selective for volatile amines to ensure good chromatographic separations and peak shapes. In addition, the column is very robust and able to withstand repeated exposure to harsh sample matrices, such as water.
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DiatoSorb-W Diatomaceous Earth: Great Chromatography Millions of Years in the Making

Virtually unlimited in supply—but only available from Restek—new DiatoSorb-W diatomaceous earth offers a reliable alternative for packed column users. After years of dealing with supply shortages and inconsistent product quality, analysts who depend on diatomaceous earth columns now have a reliable new source. Restek now uses DiatoSorb-W as the exclusive replacement to the diatomaceous earth that was previously used in our standard and Silcoport W GC packed columns lines. All DiatoSorb-W material undergoes rigorous quality testing to ensure high purity and dependable performance. DiatoSorb-W material is available in acid-washed (WAW), non-acid washed (WNAW), and high-performance (WHP) varieties.
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Influencing Selectivity in LC-MS Peptides Analysis on the Raptor ARC-18 Column

Methods for LC-MS peptide analysis often use acidified mobile phases, which can alter retention and selectivity. Here, we demonstrate the effects of modifying acid type, acid concentration, temperature, and gradient slope using several test probes. A Raptor ARC-18 column was employed for this work because it is sterically protected making it extremely stable and resistant to acid damage at low pHs, which is an important characteristic when developing LC-MS methods for peptide analysis.
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Force LC Columns Brochure

Force LC columns are long-lasting and reproducible, even under the stress of UHPLC. Premium quality is backed by the strength of our 100% Pure Satisfaction guarantee. And perhaps most important, Force LC columns are fully scalable between 3 or 5 µm HPLC and 1.8 µm UHPLC, so you can easily transfer and optimize methods without extensive calculations.
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Trace-Level Analysis of Melamine and Related Compounds by LC-MS/MS

The analysis of melamine and related compounds is critical in protecting consumers from adulterated food products. While these highly polar analytes are difficult to retain and accurately quantify on many columns, the Raptor HILIC-Si column and LC-MS/MS method shown here allow quick and complete separations, so melamine and related compounds can be accurately identified and quantified even at residual levels.
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Highly Selective LC-MS/MS Analysis of Mycotoxins from Multiple Classes

Mycotoxin contamination of crops is not only a public health concern, but it also has a huge impact on the global economy. This highly selective LC-MS/MS analysis of 20 mycotoxins in just 9 minutes allows scientists to accurately identify toxins, to monitor food products for contamination, and to support control strategies that prevent economic loss.
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Fast, Accurate LC-MS/MS Method for Folate Deficiency Biomarkers in Plasma

LC-MS/MS methods for folate deficiency biomarkers in plasma are complicated by the presence of matrix phospholipids and lysophospholipids. These interferences are problematic with reversed-phase LC because they can suppress response, reduce accuracy, and contaminate the MS source. Using a Raptor HILIC-Si column and the HILIC method shown here, folate deficiency biomarkers are completely separated from matrix interferences, allowing accurate determinations to be made in a fast, 5-minute analysis.
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All Matrix Interferences Resolved

Typical methods for EtG and EtS analysis have several limitations: poor resolution from matrix components, long run times that limit sample throughput, and short column lifetimes. Restek’s new Raptor EtG/EtS column consistently retains and resolves EtG and EtS from matrix interferences, providing fast, accurate, and reliable results injection after injection.
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