Acetonitrile Shortage:
Short-Term & Long-Term Solutions
Acetonitrile, chemical formula CH3CN, is the most commonly used organic solvent in HPLC & HILIC analyses.
The downturn in plastics manufacture, of which acetonitrile is a byproduct, has contributed to the current shortage.
Labs need both short-term measures, to cope with the expense and logistical impact of the acetonitrile shortage,
and long-term solutions, to reduce overall solvent consumption and increase analytical versatility.
Below is a collection of resources to help analysts adapt to the challenges presented by the limited acetonitrile supply.
- Short-Term Help With Acetonitrile Consumption
- The current acetonitrile shortage has labs scrambling to adjust to limited supplies and increased costs. Here's how to scale down solvent use in methods that depend on acetonitrile.
- Tech Tip – Reducing Column Internal Diameter
- Scaling down column size is simple to do and can help reduce solvent use. Here's an easy-to-follow example that teaches you how to reduce column internal diameter.
- Long-Term Strategies To Eliminate Acetonitrile Dependency
- Developing methods using alternate solvents is an effective long-term way to reduce acetonitrile use. Here we discuss how stationary phase choice can influence acetonitrile consumption.
- More information about Biphenyl HPLC Columns
- Discover how to get better resolution of your target compounds using the tunable selectivity of Biphenyl LC columns. Get true orthogonal separations using methanol instead of acetonitrile.
- UHPLC: Explaining the Small Particle Advantage
- UHPLC is an effective way to both reduce acetonitrile use and increase sample throughput. Take advantage of this versatile technique in method development or by scaling down existing methods.
- HPLC Applications Using Alternatives to Acetonitrile
- Chromatograms and conditions for a variety of compounds separated using non-acetonitrile mobile phases.
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