Pharmaceutical Solutions

• The ultimate high performance fused silica capillary column.
• Featured Application—Two Options for Analyzing Potential Genotoxic Impurities

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• Huge savings on HPLC detector lamps for select instruments.
• Our lamps meet the critical and demanding performance and product lifetime criteria that a pharmaceutical lab requires.

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• National Scientific’s certified vial kit provides the extra assurance you need for consistent data quality.
• Each packing includes a certificate of testing.

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• Cost-effective, reliable filtration.
• Protect analytical columns and instruments.
• Achieve more reproducible analyses.

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• USP equivalent standards for the revised USP <467> general chapter—compliance without the cost—compare prices today.
• The only complete source for USP <467>.

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• LC/MS and GC/MS Analysis of Potential Genotoxic Impurities in Active Pharmaceutical Ingredients (20 minutes)
• The Analysis of Residual Solvent Impurities: Implementing USP <467> Residual Solvents
• Using Phenyl Column Chemistry to Optimize Reversed Phase Separations
• Troubleshooting the Acetonitrile Shortage: Strategies for Today and Tomorrow

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Develop impurity methods faster and more efficiently using a single column that combines the selectivity of a 624 with the thermal stability of a 1 or 5 type column. The new Rxi®-624Sil MS column offers good retention of polar compounds, mass spec compatibility, and unsurpassed inertness, making it the most broadly applicable GC column available to the pharmaceutical industry.
lit. cat.# PHFL1245 (1.1mb PDF)

This reference details requirements for successfully implementing the revised USP <467> method (July, 2008). Includes a review of headspace fundamentals, USP <467> revision method details, chromatography for Procedures A, B, and C, and technical tips for optimization.
lit. cat.# PHFL1018A (470kb PDF)

Ultra II™ is the first LC column line specifically designed for universal application and completely scalable chromatography, from conventional to ultra-high pressure systems. Available in a wide range of phases, including traditional and unique chemistries.
lit. cat.# GNTS1177 (393kb PDF)

Biphenyl columns provide both high hydrophobic retention and aromatic selectivity in the same column. Orthogonal separations can be achieved with simple mobile phase changes, giving markedly better separations for a wide variety of molecules.
lit. cat.# GNFL1096 (523kb PDF)

Save time and money—let Restek custom blend reference standards specifically for your residual solvent testing needs! | Download (76kb pdf)

Not all column deactivations are appropriate for analyzing basic compounds. Here we demonstrate the effect of column inertness on peak shape, and discuss its role in improving method accuracy, sensitivity, and shortening development time.
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Restek Technical Support can provide you with custom residual solvent methods in minutes using Pro ezGC software. Review a customer example and learn how to request a method specific to your application.
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Restek has developed the first QuEChERS-based method for determining pesticide residues in dietary supplements. This simple, cost-effective procedure reduces matrix interferences as well as sample prep variation among technicians.
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Not all G43 columns are equivalent. New Rxi®-624Sil MS columns reliably produce improved resolution and sensitivity, increasing system suitability pass rates and ensuring more productive laboratory time.
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Significant savings can be obtained without the costly upgrade to UHPLC. This famotidine example illustrates how a 90% reduction in analysis time and solvent volume resulted from strategic LC column choices.
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Laboratory needs for analyzing PGIs in API vary. Here we developed both a fast analysis of sulfonate esters on the Rxi®-5Sil MS column, and a comprehensive method for both sulfonate esters and alkyl halides on the Rtx®-200 column.
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Here we demonstrate the importance of stationary phase choice in UHPLC separations. By optimizing selectivity for your analytes of interest faster separations can be achieved without compromising resolution.
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Resources to assist analytical laboratories in coping with the limited availability of acetonitrile. Ways to reduce solvent consumption, shorten analysis times, and switch to alternative mobile phases.
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