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Influencing Selectivity in LC-MS Peptides Analysis on the Raptor ARC-18 Column

Author: Sharon Lupo, Frances Carroll

Restek Corporation

Published By: Restek Corporation

Year of Publication: 2017

Link: http://www.restek.com/Technical-Resources/Technical-Library/Pharmaceutical/pharma_PHAN2615-UNV

Abstract:

Methods for LC-MS peptide analysis often use acidified mobile phases, which can alter retention and selectivity. Here, we demonstrate the effects of modifying acid type, acid concentration, temperature, and gradient slope using several test probes. A Raptor ARC-18 column was employed for this work because the stationary phase ligand is sterically protected, making it extremely stable and resistant to acid damage at low pHs, which is an important characteristic when developing LC-MS methods for peptide analysis.

Method Development and Column Selection: How the FluoroPhenyl Phase Provides the Power of HILIC and Reversed-Phase Modes in One Column

Author: Sharon Lupo, Frances Carroll

Restek Corporation

Published By: Restek Corporation

Year of Publication: 2017

Link: http://www.restek.com/Technical-Resources/Technical-Library/General-Interest/gen_GNAR2613

Abstract:

Column selection is an important part of method development, as the quality of critical separations is determined in large part by the retention and selectivity of the analytical column. Although C18 columns are commonly employed, FluoroPhenyl columns provide an orthogonal alternative for method development because they incorporate multiple retention mechanisms and can be used in both reversed-phase (RP) and hydrophilic interaction liquid chromatography (HILIC) modes. This paper explores how FluoroPhenyl columns can be used to improve separations, especially for compounds that are difficult to analyze on a C18, such as basic analytes or small polar compounds.

Analysis of Synthetic Cannabinoids and Metabolites: Adding New Compounds to an Existing LC-MS/MS Method

Author: Sharon Lupo, Frances Carroll

Restek Corporation

Published By: Restek Corporation

Year of Publication: 2017

Link: http://www.restek.com/Technical-Resources/Technical-Library/Foods-Flavors-Fragrances/fff_FFAN2614-UNV

Abstract:

The analysis of synthetic cannabinoids and their metabolites can be a difficult and challenging task. Keeping up with the ever-growing list of synthetic cannabinoids that illicit drugmakers produce further complicates the analysis. As shown here, the retention and selectivity of the Raptor Biphenyl column allow new drugs to be added to an existing method, providing labs with an important vehicle for improving efficiency and productivity.