Q-sep Extraction Salts Make QuEChERS Even Easier

For years, the QuEChERS approach has made sample preparation faster and easier than traditional methods. Now, the new Q-sep extraction salts from Restek make an easy technique even simpler. Restek’s new, improved design provides the salts in a more granular form, so they flow freely and are easier to pour than powders. The convenient slim packets are easy to open and fit perfectly into extraction tubes, ensuring complete transfer without any spills. These new extraction salts offer the same technical performance you’ve come to expect from the Q-sep line of QuEChERS products, just redesigned for your convenience. Keep your workflow running smoothly with new Q-sep extraction salts from Restek!

www.restek.com/quechers

Trace-Level Analysis of Metanephrines in Plasma by HILIC LC-MS/MS

Author: Shun-Hsin Liang and Frances Carroll

Published By: Restek Corporation

Year of Publication: 2017

Link: http://www.restek.com/Technical-Resources/Technical-Library/Clinical-Forensic-Toxicology/cft_CFAN2801-UNV

Abstract: 

Highly sensitive analysis of metanephrines and in plasma is critical in the diagnosis and treatment of pheochromocytoma and paraganglioma. Here, a HILIC LC-MS/MS method was developed using a Raptor HILIC-Si column because this approach provides retention of all target compounds in highly organic mobile phases, thus providing the increased sensitivity needed to reach low detection limits. Data from linearity, accuracy, and precision testing demonstrate that accurate results are consistently obtained—even at trace levels—for these important clinical biomarkers.

Analysis of Fentanyl and Its Analogues in Human Urine by LC-MS/MS

Author: Shun-Hsin Liang and Frances Carroll

Published By: Restek Corporation

Year of Publication: 2017

Link: http://www.restek.com/Technical-Resources/Technical-Library/Clinical-Forensic-Toxicology/cft_CFAN2820-UNV

Abstract: 

Synthetic opioid drugs, such as fentanyl and sufentanil, have very high analgesic potency. Abuse of these prescription painkillers—along with a rapidly growing list of illicit analogues—is a significant public health problem. In this study, we developed a simple dilute-and-shoot method that provides a fast 3.5 minute analysis of fentanyl and related compounds (norfentanyl, acetyl fentanyl, alfentanil, butyryl fentanyl, carfentanil, remifentanil, and sufentanil) in human urine by LC-MS/MS using a Raptor Biphenyl column.

Restek Unleashes Superior Raptor Performance on Your UHPLC Analyses — Now with 1.8 μm Particles

Raptor LC columns have been providing higher efficiencies, faster analyses, and rock-solid reliability to HPLC users for several years.

And they have just evolved again.

Restek has brought the benefits of Raptor columns to those who have made the leap to UHPLC instruments, yet are still looking to boost their efficiencies further. Already sold with 2.7 and 5 μm superficially porous particles (SPP), Raptor columns are now available with 1.8 μm particles specifically for use with UHPLC. Choose from four distinctive Restek phase chemistries: Biphenyl, ARC-18, C18, and FluoroPhenyl.

Raptor 1.8 μm columns are designed and QC tested for maximum lifetime under UHPLC pressures. And, because they are Raptor SPP LC columns, they offer the peak capacity, selectivity, and reproducibility that analysts have learned to depend on from Restek.

Outfit your UHPLC with evolutionary Raptor 1.8 μm columns today at www.restek.com/raptor

About Raptor SPP LC Columns:
Superficially porous particles (commonly referred to as SPP or “core-shell” particles) changed the world of LC by dramatically boosting column efficiency and reducing analysis times, but they were only the beginning. With Raptor LC columns, Restek chemists have combined the speed of SPP with the resolution of highly selective USLC technology. This new species of chromatographic column allows you to more easily achieve peak separation and faster analysis times without expensive UHPLC instrumentation. Raptor LC columns provide the practicing analyst with the most powerful tools available for fast, efficient method development and increased sample throughput. And, because they are from Restek, Raptor LC columns are backed by manufacturing and quality systems you trust along with internationally renowned Plus 1 service.

The Effects of LC Particle Choice on Column Performance: Raptor 1.8 µm Superficially Porous Particles (SPP) for UHPLC Analyses

Published By: Restek Corporation

Year of Publication: 2017

Link: www.restek.com/Technical-Resources/Technical-Library/General-Interest/gen_GNAR2803-UNV

Abstract: Superficially porous particles (commonly referred to as SPP or “core-shell” particles) have been proven to provide fast and efficient LC separations. These particles feature a solid, impermeable core enveloped by a thin, porous layer of silica that offers significantly higher efficiency and sensitivity than traditional fully porous particles (FPP). At launch, Raptor SPP LC columns were touted for their selectivity and for their ability to help customers achieve faster separations with their existing HPLC instruments. With the launch of Raptor 1.8 µm columns, this superior Raptor performance has been unleashed on your UHPLC analyses. But, what exactly does that mean? In this technical note, we will explore the benefits of using Raptor 1.8 µm LC columns in your UHPLC instrument with a focus on peak capacity, column lifetime, and selectivity.

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