Derivatization Reagents: Silylation Reagents

Replaces active hydrogen, reducing polarity and making the compounds more volatile.
Increases stability of derivatives.

Silylation is the most widely used derivatization procedure for sample analysis by GC. In silylation, an active hydrogen is replaced by an alkylsilyl group such as trimethylsilyl (TMS) or tert-butyldimethylsilyl (tert-BDMS). Silyl derivatives are more volatile, less polar, and more thermally stable. As a result, GC separation is improved and detection is enhanced.
Both TMS and tert-BDMS reagents are suitable for a wide variety of compounds and can be used for many GC applications. Note that silylation reagents are generally moisture sensitive and must be sealed to prevent deactivation.

Description	CAS #	qty.	Cat.#	Price	Wish list	Cart
MSTFA (N-methyl-N-trimethylsilytrifluoroacetamide)	24589-78-4	10-pk. (10x1g)	35600

MSTFA (N-methyl-N-trimethylsilytrifluoroacetamide)	24589-78-4	25g vial	35601

MSTFA w/1% TMCS (N-methyl-N-trimethylsilytrifluoroacetamide w/1% trimethylchlorosilane)	24589-78-4	10-pk. (10x1g)	35602

MSTFA w/1% TMCS (N-methyl-N-trimethylsilytrifluoroacetamide w/1% trimethylchlorosilane)	24589-78-4	25g vial	35603

BSTFA (N,O-bis[trimethylsilyl]trifluoroacetamide)	25561-30-2	10-pk. (10x1g)	35604

BSTFA (N,O-bis[trimethylsilyl]trifluoroacetamide)	25561-30-2	25g vial	35605

BSTFA w/1% TMCS (N,O-bis[trimethylsilyltrifluoroacetamide] w/1% trimethylchlorosilane)	25561-30-2	10-pk. (10x1g)	35606

BSTFA w/1% TMCS (N,O-bis[trimethylsilyltrifluoroacetamide] w/1% trimethylchlorosilane)	25561-30-2	25g vial	35607

MTBSTFA w/1% TBDMCS (N-methyl-N[tert-butyldimethylsilyl trifluoroacetamide] w/1% tert-butyldimethylchlorosilane)	77377-52-7	10-pk. (10x1g)	35608

MTBSTFA w/1% TBDMCS (N-methyl-N[tert-butyldimethylsilyl trifluoroacetamide] w/1% tert-butyldimethylchlorosilane)	77377-52-7	25g vial	35610

TMCS (trimethylchlorosilane)	75-77-4	10-pk. (10x1g)	35611

TMCS (trimethylchlorosilane)	75-77-4	25g vial	35612