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HPLC & UHPLC Analytical Columns

HPLC & UHPLC Analytical Columns

Products

Raptor ARC-18 LC Columns (USP L1)

  • Ideal for high-throughput LC-MS/MS applications with minimal sample preparation.
  • Well-balanced retention profile for better detection and integration of large, multiclass analyte lists.
  • Sterically protected to endure low-pH mobile phases without sacrificing retention or peak quality.
  • Part of Restek’s Raptor LC column line featuring 1.8, 2.7, and 5 µm SPP core-shell silica.

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Raptor C18 LC Columns (USP L1)

  • A traditional end-capped C18 ideal for general-purpose use in reversed-phase chromatography.
  • Wide pH range (2–8) provides excellent data quality for many applications, matrices, and compounds.
  • Offers the highest hydrophobic retention of any Raptor phase.
  • Part of Restek’s Raptor LC column line featuring 1.8, 2.7, and 5 µm SPP core-shell silica.

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Raptor Biphenyl LC Columns (USP L11)

  • Ideal for bioanalytical testing applications like drug and metabolite analyses.
  • Heightened selectivity and retention for compounds that are hard to resolve or elute early on C18 and other phenyl chemistries.
  • Limits ionization suppression and allows simple, MS-friendly mobile phases.
  • Part of Restek’s Raptor LC column line featuring 1.8, 2.7, and 5 µm SPP core-shell silica.

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Raptor FluoroPhenyl LC Columns (USP L43)

  • Capable of both reversed-phase and HILIC separations.
  • Ideal for increasing sensitivity and selectivity in LC-MS analyses.
  • Offers increased retention for charged bases.
  • Part of Restek’s Raptor LC column line featuring 1.8, 2.7, and 5 µm SPP core-shell silica.
  • Switch to a Raptor FluoroPhenyl LC column when you need more retention and selectivity for basic and hydrophilic compounds than you can achieve on a C18.

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Raptor HILIC-Si LC Columns (USP L3)

  • HILIC silica column designed for increased retention of polar compounds without ion-pairing reagents.
  • 2.7 µm Raptor core-shell particles provide the speed of SPP, with greater efficiency and capacity than 5 µm particles.
  • Ideal for increasing sensitivity and selectivity in LC-MS analyses.
  • Fully compatible with both HPLC and UHPLC when using low back-pressure HILIC mobile phases.
  • Switch to a Raptor HILIC-Si LC column when you need more retention and resolution of hydrophilic, polar analytes.

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Force FluoroPhenyl LC Columns (USP L43)

  • Capable of both reversed-phase and HILIC separations.
  • Ideal for increasing sensitivity and selectivity in LC-MS analyses.
  • Offers increased retention for charged bases.

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Force C18 LC Columns (USP L1)

  • A traditional end-capped C18 ideal for general-purpose use in reversed-phase chromatography.
  • Wide pH range (2–8) provides excellent data quality for many applications, matrices, and compounds.
  • Offers high hydrophobic retention.

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Force Biphenyl LC Columns (USP L11)

  • Ideal for bioanalytical testing applications like drug and metabolite analyses.
  • Heightened selectivity and retention for compounds that are hard to resolve or elute early on C18 and other phenyl chemistries.
  • Limits ionization suppression and allows simple, MS-friendly mobile phases.
  • Restek’s most popular LC stationary phase.

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Ultra Biphenyl Columns (USP L11)

Stationary Phase Category: phenyl (L11)
Ligand Type: unique Biphenyl
Particle: 3 µm or 5 µm, spherical
Pore Size: 100 Å
Carbon Load: 15%
End-Cap: yes
Surface Area: 300 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Pinnacle DB Biphenyl Columns (USP L11)

Stationary Phase Category: phenyl (L11)
Ligand Type: unique Biphenyl
Particle: 1.9 µm, 3 µm, or 5 µm, spherical
Pore Size: 140 Å
Carbon Load: 8%
End-Cap: yes
Surface Area: 150 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Roc Silica HPLC Columns (USP L3)

  • Conventional HPLC column built to be the cornerstone for your lab; pressure rated for any 400 bar HPLC system.
  • Solid and reliable—delivers the peak shape, reproducibility, ruggedness, and performance you demand.
  • Exceptional value for routine analyses and large-volume workflows—high-purity, fully porous silica backed by quality manufacturing features a variety of phases to fit most HPLC methods.
  • Ideal for a wide range of applications from food to pharma;
    5 phases cover 98% of USP methods.

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Roc Cyano HPLC Columns (USP L10)

  • Conventional HPLC column built to be the cornerstone for your lab; pressure rated for any 400 bar HPLC system.
  • Solid and reliable—delivers the peak shape, reproducibility, ruggedness, and performance you demand.
  • Exceptional value for routine analyses and large-volume workflows—high-purity, fully porous silica backed by quality manufacturing features a variety of phases to fit most HPLC methods.
  • Ideal for a wide range of applications from food to pharma;
    5 phases cover 98% of USP methods.

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Roc Phenyl-Hexyl HPLC Columns (USP L11)

  • Conventional HPLC column built to be the cornerstone for your lab; pressure rated for any 400 bar HPLC system.
  • Solid and reliable—delivers the peak shape, reproducibility, ruggedness, and performance you demand.
  • Exceptional value for routine analyses and large-volume workflows—high-purity, fully porous silica backed by quality manufacturing features a variety of phases to fit most HPLC methods.
  • Ideal for a wide range of applications from food to pharma;
    5 phases cover 98% of USP methods.

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Roc C18 HPLC Columns (USP L1)

  • Conventional HPLC column built to be the cornerstone for your lab; pressure rated for any 400 bar HPLC system.
  • Solid and reliable—delivers the peak shape, reproducibility, ruggedness, and performance you demand.
  • Exceptional value for routine analyses and large-volume workflows—high-purity, fully porous silica backed by quality manufacturing features a variety of phases to fit most HPLC methods.
  • Ideal for a wide range of applications from food to pharma;
    5 phases cover 98% of USP methods.

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Roc C8 HPLC Columns (USP L7)

  • Conventional HPLC column built to be the cornerstone for your lab; pressure rated for any 400 bar HPLC system.
  • Solid and reliabledelivers the peak shape, reproducibility, ruggedness, and performance you demand.
  • Exceptional value for routine analyses and large-volume workflowshigh-purity, fully porous silica backed by quality manufacturing features a variety of phases to fit most HPLC methods.
  • Ideal for a wide range of applications from food to pharma;
    5 phases cover 98% of USP methods.

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Pinnacle DB IBD UHPLC Columns (USP L68)

Stationary Phase Category: polar-embedded alkyl (L68)
Ligand Type: proprietary polar functional embedded alkyl
Particle: 1.9 µm, spherical
Pore Size: 140 Å
Carbon Load: proprietary
End-Cap: no
Surface Area: 150 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Pinnacle DB PAH UHPLC Columns

Particle: 1.9 µm, spherical
Pore Size: 140 Å
Carbon Load: proprietary
End-Cap: no
Surface Area: 150 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Pinnacle DB PFP Propyl Columns (USP L43)

Stationary Phase Category: fluorophenyl propyl (L43)
Ligand Type: pentafluorophenyl propyl
Particle: 1.9 µm, 3 µm, or 5 µm, spherical
Pore Size: 140 Å
Carbon Load: 6%
End-Cap: yes
Surface Area: 150 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Viva Biphenyl Columns (USP L11)

Stationary Phase Category: phenyl (L11)
Ligand Type: Biphenyl
Particle: 5 µm, spherical
Pore Size: 300 Å
Carbon Load: 7%
End-Cap: yes
Surface Area: 100 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Viva PFP Propyl Columns (USP L43)

Stationary Phase Category: fluorophenyl propyl (L43)
Ligand Type: pentafluorophenyl propyl
Particle: 5 µm, spherical
Pore Size: 300 Å
Carbon Load: 5%
End-Cap: yes
Surface Area: 100 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Viva C4 Columns (USP L26)

Stationary Phase Category: C4, butylsilane (L26)
Ligand Type: monomeric C4
Particle: 5 µm, spherical
Pore Size: 300 Å
Carbon Load: 3.5%
End-Cap: yes
Surface Area: 100 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Viva C8 Columns (USP L7)

Stationary Phase Category: C8, octylsilane (L7)
Ligand Type: monomeric C8
Particle: 5 µm, spherical
Pore Size: 300 Å
Carbon Load: 5%
End-Cap: yes
Surface Area: 100 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Viva C18 Columns (USP L1)

Stationary Phase Category: C18, octadecylsilane (L1)
Ligand Type: monomeric C18
Particle: 3 µm or 5 µm, spherical
Pore Size: 300 Å
Carbon Load: 9%
End-Cap: yes
Surface Area: 100 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Viva Silica Columns (USP L3)

Stationary Phase Category: bare silica (L3)
Ligand Type: none
Particle: 5 µm, spherical
Pore Size: 300 Å
Carbon Load: n/a
End-Cap: n/a
Surface Area: 100 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Pinnacle DB Silica Columns (USP L3)

Stationary Phase Category: bare silica (L3)
Ligand Type: none
Particle: 1.9 µm, 3 µm, or 5 µm, spherical
Pore Size: 140 Å
Carbon Load: n/a
End-Cap: n/a
Surface Area: 150 m2/g
pH Range: 2.5 to 8.0
Maximum Temperature: 80 °C

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Pinnacle DB Cyano Columns (USP L10)

Stationary Phase Category: cyano (L10)
Ligand Type: cyanopropylsilane
Particle: 1.9 µm or 5 µm, spherical
Pore Size: 140 Å
Carbon Load: 4%
End-Cap: yes
Surface Area: 150 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Pinnacle DB C8 Columns (USP L7)

Stationary Phase Category: C8, octylsilane (L7)
Ligand Type: monomeric C8
Particle: 1.9 µm, 3 µm, or 5 µm, spherical
Pore Size: 140 Å
Carbon Load: 6%
End-Cap: yes
Surface Area: 150 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Pinnacle DB C18 Columns (USP L1)

Stationary Phase Category: C18, octadecylsilane (L1)
Ligand Type: monomeric C18
Particle: 1.9 µm, 3 µm, or 5 µm, spherical
Pore Size: 140 Å
Carbon Load: 11%
End-Cap: yes
Surface Area: 150 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Allure Silica Column for MOSH/MOAH Analysis

Particle: 5 µm, spherical
Pore Size: 60 Å
Carbon Load: n/a
End-cap: n/a
Surface Area: 450 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

Highly retentive phase for normal phase separations. Very high surface area, Type B silica packing.

Ideal for MOSH/MOAH analysis by EN 16995. For compatibility with Axel Semrau and other automated systems, add the Level 3 Trident column protection system and Allure Silica guard cartridge listed in Related Products.

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Raptor EtG/EtS LC Column

  • Proven performance for accurate, reliable ethyl glucuronide (EtG) and ethyl sulfate (EtS) analysis.
  • Strong retention consistently resolves analytes from matrix interferences.
  • Long column lifetime ensures consistent performance injection after injection.
  • Fast, 4-minute, dilute-and-shoot LC-MS/MS analysis supports high sample throughput.

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USLC Method Development Toolbox

All the Right ToolsAll in One Toolbox

  • Ultra Selective Liquid Chromatography (USLC) method development toolbox contains all four USLC stationary phases in one convenient package.
  • Available for UHPLC (1.9 μm) and HPLC (3 or 5 μm) in 50, 100, or 150 mm lengths.

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Ultra Aromax Columns (USP L11)

Stationary Phase Category: phenyl (L11)
Ligand Type: proprietary phenyl ligand
Particle: 3 µm or 5 µm, spherical
Pore Size: 100 Å
Carbon Load: 17%
End-Cap: yes
Surface Area: 300 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Ultra PFP Propyl Columns (USP L43)

Stationary Phase Category: fluorophenyl propyl (L43)
Ligand Type: pentafluorophenyl propyl
Particle: 3 µm or 5 µm, spherical
Pore Size: 100 Å
Carbon Load: 11%
End-Cap: yes
Surface Area: 300 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Pinnacle II PAH HPLC Columns

Particle: 4 µm, spherical
Pore Size: 110 Å
Carbon Load: proprietary
End-Cap: no
Surface Area: 180 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Allure AK Columns

Particle: 5 µm, spherical
Pore Size: 60 Å
Carbon Load: proprietary
End-Cap: yes
Surface Area: 450 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Ultra Quat Columns

Particle: 3 µm or 5 µm, spherical
Pore Size: 100 Å
Carbon Load: proprietary
Surface Area: 300 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Allure Organic Acids Columns

Particle: 5 µm, spherical
Pore Size: 60 Å
Carbon Load: proprietary
End-Cap: no
Surface Area: 450 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Ultra Carbamate Columns

Particle: 3 µm or 5 µm, spherical
Pore Size: 100 Å
Carbon Load: proprietary
Surface Area: 300 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Ultra Silica Columns (USP L3)

Stationary Phase Category: bare silica (L3)
Ligand Type: none
Particle: 3 µm or 5 µm, spherical
Pore Size: 100 Å
Carbon Load: n/a
End-Cap: n/a
Surface Area: 300 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Ultra IBD Columns (USP L68)

Specialized Columns for Mixed Polar and Nonpolar Compounds

Stationary Phase Category: polar-embedded alkyl (L68)
Ligand Type: proprietary polar functional embedded alkyl
Particle: 3 µm or 5 µm, spherical
Pore Size: 100 Å
Carbon Load: 12%
End-Cap: no
Surface Area: 300 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Ultra Cyano Columns (USP L10)

Stationary Phase Category: cyano (L10)
Ligand Type: cyanopropylsilane
Particle: 3 µm or 5 µm, spherical
Pore Size: 100 Å
Carbon Load: 8%
End-Cap: yes
Surface Area: 300 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Ultra Aqueous C18 Columns (USP L1)

Stationary Phase Category: modified C18 (L1)
Ligand Type: proprietary polar modified and functionally bonded C18
Particle: 3 µm or 5 µm, spherical
Pore Size: 100 Å
Carbon Load: 15%
End-Cap: no
Surface Area: 300 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Ultra C18 Columns (USP L1)

Excellent for a wide range of analyses

Stationary Phase Category: C18, octadecylsilane (L1)
Ligand Type: monomeric C18
Particle: 3 µm or 5 µm, spherical
Pore Size: 100 Å
Carbon Load: 20%
End-Cap: yes
Surface Area: 300 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Ultra C8 Columns (USP L7)

Excellent for a wide range of analyses

Stationary Phase Category: C8, octylsilane (L7)
Ligand Type: monomeric C8
Particle: 3 µm or 5 µm, spherical
Pore Size: 100 Å
Carbon Load: 12%
End-Cap: yes
Surface Area: 300 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Ultra C4 Columns (USP L26)

Stationary Phase Category: C4, butylsilane (L26)
Ligand Type: monomeric C4
Particle: 3 µm or 5 µm, spherical
Pore Size: 100 Å
Carbon Load: 9%
End-Cap: yes
Surface Area: 300 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Ultra C1 Columns (USP L13)

Stationary Phase Category: trimethylsilane (L13)
Ligand Type: monomeric C1
Particle: 3 µm or 5 µm, spherical
Pore Size: 100 Å
Carbon Load: 5%
End-Cap: yes
Surface Area: 300 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Ultra Amino Columns (USP L8)

Stationary Phase Category: amino (L8)
Ligand Type: aminopropylsilane
Particle: 3 µm or 5 µm, spherical
Pore Size: 100 Å
Carbon Load: 2%
End-Cap: no
Surface Area: 300 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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Allure Silica Columns (USP L3)

Particle: 5 µm, spherical
Pore Size: 60 Å
Carbon Load: n/a
End-cap: n/a
Surface Area: 450 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

Highly retentive phase for normal phase separations. Very high surface area, Type B silica packing.

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Pinnacle DB Aqueous C18 Columns (USP L1)

Stationary Phase Category: modified C18 (L1)
Ligand Type: proprietary polar modified and functionally bonded C18
Particle: 1.9 µm, 3 µm, or 5 µm, spherical
Pore Size: 140 Å
Carbon Load: 6%
End-Cap: no
Surface Area: 150 m2/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

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