Pharmaceutical Solutions

Pharmaceutical Solutions

Raptor Biphenyl LC Columns (USP L11)

  • Ideal for bioanalytical testing applications like drug and metabolite analyses.
  • Heightened selectivity and retention for compounds that are hard to resolve or elute early on C18 and other phenyl chemistries.
  • Limits ionization suppression and allows simple, MS-friendly mobile phases.
  • Part of Restek’s Raptor LC column line featuring 1.8, 2.7, and 5 µm SPP core-shell silica.

Pinnacle DB HPLC & UHPLC Columns

  • Base deactivated silica—ideal for analysis of basic compounds or bases mixed with acids/neutrals.
  • Available phases: Biphenyl, C8, Cyano, Silica, Phenyl, PFP Propyl, PAH, IBD, C18, Aqueous C18.
  • 1.9 µm columns for UHPLC and 3 or 5 µm columns for standard HPLC.

Rxi Capillary GC Columns

Leverage the outstanding inertness, low bleed, and high reproducibility of Rxi GC Columns with 3-in-1 technology to gain:
  • Accurate Data
  • The Right Results Fast
  • Maximized Instrument Uptime

Certified Autosampler Vial Kits

Certified 2.0 mL Screw-Thread Vials

  • Certificates enclosed with each kit.
  • Vials of clear or amber borosilicate glass with ID marking spots.
  • Closures with pre-inserted septa.
  • Each kit sealed for integrity.

Syringe Filters with Luer Lock Inlet

  • Luer lock inlet offers leak-tight syringe connection.
  • Variety of filter types, porosities, and diameters.
  • Color coded for easy identification.
  • Rugged polypropylene housing.
  • Autoclavable to 121 °C for 15 minutes.
  • Quantity break pricing for greater savings.
Note: Syringe filters are for laboratory use only.

USP Residual Solvent Standards

  • USP equivalent standards for the revised USP <467> general chapter—compliance without the cost—compare prices today.
  • The only complete source for USP <467>.


for Agilent HPLC Systems


for Waters Detectors

Clinical, Forensic & Toxicology

USLC Columns Put the Right Tools in Your LC Method Development Toolbox - Understanding Selectivity in Reversed Phase Separations – A Simplified Approach to HPLC and UHPLC Column Selection

Column selectivity has the most significant influence on chromatographic peak separation, or resolution, so choosing the right column can greatly speed up HPLC and UHPLC method development. In this article, we discuss column choice and identify a set of just 4 stationary phases—Restek’s USLC column set—that encompasses the widest range of reversed phase selectivity available today.


Two Options for Analyzing Potential Genotoxic Impurities in Active Pharmaceutical Ingredients

Two options for the analysis of PGIs in API have been developed by Merck and Restek to meet different laboratory needs. The first option is a fast method for the analysis of sulfonate esters on the Rxi-5Sil MS column. The second option is a comprehensive method for the analysis of both sulfonate esters and alkyl halides on the Rtx-200 column. Both methods require very little sample preparation, which helps increase laboratory productivity.

General Interest

Pesticides in Dietary Supplements: - Advantages of QuEChERS vs. PAM 303

Restek has developed the first QuEChERS-based method for determining pesticide residues in dietary supplements. This simple, cost-effective procedure reduces matrix interferences as well as sample prep variation among technicians.

PDF Document

Determining Pesticides in Dietary Supplements with QuEChERS Extraction, Cartridge SPE, and GCxGC-TOFMS

The novel approach used here combines QuEChERS extraction, cartridge SPE cleanup, and GCxGC-TOFMS analysis, resulting in good recoveries for a wide range of pesticides in dietary supplements. Matrices include dandelion root, sage, and a multi-herb finished product.

PDF Document

USLC Columns: Choose Columns Fast. Develop Methods Faster.

Restek USLC columns offer the widest range of selectivity available and are an integral part of successful method development. Ideal for column switching systems, these columns provide orthogonal separations to create optimal resolution and robust methods—all in a 4-column set.

PDF Document

USLC Column Selection & Mobile Phase Adjustment Guide

USLC columns and this guide will help you easily choose the right stationary phase to target nearly any analyte in reversed phase or HILIC method development. It will also help you adjust your mobile phase to further improve results without guesswork or wasted time.

PDF Document

Rxi-624Sil MS Columns—Exceptionally Inert, Low Bleed Columns for Volatiles Analysis

Analyze volatile compounds and polar analytes with greater confidence using Rxi-624Sil MS columns. Optimized selectivity, higher inertness, and lower bleed result in reliable separations and accurate, trace-level determinations. Includes environmental and pharmaceutical applications.

PDF Document

Excellent LC-MS Separation of Penicillins and Cephalosporins Using Ultra IBD Columns

Unlike C18 columns, Ultra IBD (intrinsically base deactivated) columns can interact in normal phase mode with analytes that possess charged functional groups, providing greater versatility for LC-MS analyses. Excellent peak shape in either normal phase mode or reversed phase mode increases sensitivity and improves quantification. The 4-page note shows example analyses of penicillins and cephalosporins.

PDF Document

Raptor Biphenyl LC Columns Brochure

Raptor LC columns combine the speed of superficially porous particles (i.e., SPP or “core-shell”) with the resolution of highly selective USLC technology. Featuring Restek's most popular LC stationary phase, the rugged Raptor Biphenyl is extremely useful for fast separations in bioanalytical testing applications like drug and metabolite analyses, especially those that require a mass spectrometer (MS). (PDF - 6071kB)

PDF Document

Dissecting Raptor LC Columns: A closer look at a new species

When we engineered our superficially porous particle (SPP or "core-shell") Raptor LC columns, we developed the bonding chemistries that are best suited to both the SPP construction and our highly selective USLC phases. But we didn't stop here. Take a closer look at a new species as we dissect the upgraded hardware and new, proprietary packing techniques behind Raptor LC columns and Raptor EXP guard columns. (PDF - 1725kB)

PDF Document

NEW! Rx-1301Sil MS GC Columns

The new Rxi-1301Sil MS column is ideal for the analysis of multiple compound classes across a range of polarities and volatilities. With its cyano-based selectivity and high thermal stability, it is the best 1301-type column for robust MS analyses.

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