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Article

Organic Volatile Impurities: Retention Time Index

Conditions used to determine retention time data are listed below.

Retention Time
Compound
ICH
Class
G16
Stabil-
wax
G16
Rtx-WAX
G43
Rtx-1301
G27
Rxi-5ms
G1
Rtx-1
NA
Rtx-200
1,1,1-trichloroethane
1
  3.96
  3.49
  5.43
  5.40
10.82
  8.35
1,1,2-trichloroethane
2
15.72
14.28
10.99
  9.77
16.75
14.94
1,1-dichloro- ethene
1
  2.23
  2.04
  2.79
  4.41
  5.73
  4.16
1,2-dichloro- ethane
1
  8.80
  7.68
  6.15
  5.46
10.38
  9.74
cis-1,2-dichloro- ethene
2
  6.50
  5.65
  4.79
  2.88
  8.71
  7.11
trans-1,2-dichloro- ethene
2
  3.63
  3.20
  3.55
  3.54
  7.17
  5.16
1,2-dimethoxyethane
2
  4.80
  4.18
  6.03
  5.54
10.98
10.63
1,4-dioxane
2
  8.55
  7.49
  7.86
  7.26
13.54
14.34
1-butanol
3
11.13
10.08
  7.18
  5.76
11.49
10.13
1-pentanol
3
14.95
13.75
11.19
  9.44
16.99
14.95
1-propanol
3
  7.69
  6.80
  4.20
  3.37
  6.81
  6.13
2-butanol
3
  7.25
  6.44
  5.08
  4.16
  8.51
  7.69
2-ethoxyethanol
2
13.99
12.70
  8.69
  7.36
13.91
13.99
2-methoxyethanol
2
12.42
11.11
  6.02
  5.14
  9.83
10.74
2-methyl-1-propanol
3
  9.32
  8.40
  6.00
  4.79
*
*
2-propanol
3
  4.81
  4.25
  3.00
  2.55
  4.91
  4.69
3-methyl-1-butanol
3
13.42
12.25
  9.86
  8.26
15.28
13.55
acetic acid
3
22.47
20.34
  6.52
  4.61
  8.84
  8.96
acetone
3
  3.02
  2.64
  2.89
  2.50
  4.64
  7.68
acetonitrile
2
  6.91
  5.83
  3.28
  2.47
  4.32
  8.89
anisole
3
18.65
17.09
17.12
16.28
25.00
22.84
benzene
1
  5.23
  4.54
  5.98
  3.83
11.63
  9.17
butyl acetate
3
  8.86
  7.88
12.12
11.38
19.43
19.63
carbon tetrachloride
1
  3.96
  3.49
  5.61
  5.90
  11.89
  7.42
chlorobenzene
2
13.91
12.54
13.55
13.14
21.56
18.48
chloroform
2
  7.31
  6.41
  5.23
  4.64
  9.18
  6.66
cumene
3
12.36
11.17
16.66
16.69
25.88
20.90
cyclohexane
2
  2.16
  2.01
  5.37
  5.89
*
*
dichloromethane
2
  5.01
  4.33
  3.31
  3.06
  5.87
  4.88
dimethylsulfoxide
3
26.47
24.43
16.62
13.01
18.81
30.95
ethanol
3
  4.98
  4.37
  2.52
  2.19
  4.03
  3.80
ethyl acetate
3
  4.08
  3.56
  4.87
  4.44
  9.04
10.35
ethyl benzene
2
10.72
  9.58
13.86
13.81
22.54
18.18
ethyl ether
3
  1.72
  1.63
  2.58
  2.67
  5.34
  3.87
ethyl formate
3
  3.16
  2.78
  3.00
  2.78
  5.46
  6.48
ethylene glycol
2
28.06
26.23
10.77
  6.63
12.59
13.86
formamide
2
32.99
30.93
11.85
  7.30
12.72
19.93
formic acid
3
24.64
22.09
  5.19
  2.60
  5.59
  5.06
heptane
3
  1.98
  1.86
  6.34
  6.98
14.18
  7.84
hexane
2
  1.65
  1.58
  3.77
  4.11
  9.06
  4.86
isobutyl acetate
3
  6.99
  6.18
10.39
  9.69
17.35
18.02
isopropyl acetate
3
  4.26
  3.74
  6.19
  5.71
11.47
12.38
methanol
2
  4.23
  3.64
  1.96
  1.80
  3.14
  2.93
methyl acetate
3
  3.19
  2.80
  3.17
  2.93
  5.80
  7.10
methylbutyl ketone
2
  9.10
  8.05
11.81
10.50
17.94
20.81
methylcyclohexane
2
  2.50
  2.30
  7.31
  7.95
15.49
  9.21
methylethyl ketone
3
  4.33
  3.76
  4.90
  4.09
  7.99
11.55
methylisobutyl
ketone
3
  6.84
  5.97
  9.64
  8.49
15.35
18.41
m-xylene
2
11.21
10.04
14.29
14.17
23.01
18.78
N,N-dimethyl- acetamide
2
20.75
19.01
12.95
13.96
21.42
30.00
N,N-dimethyl- formamide
2
18.04
16.26
13.09
10.23
16.52
26.19
nitromethane
2
11.82
10.31
  4.84
  3.53
  6.30
12.01
N-methylpyrrolidone
2
29.84
27.86
25.09
21.85
29.99
38.08
o-xylene
2
12.79
11.51
15.46
15.26
24.23
20.33
pentane
3
  1.49
  1.45
  2.39
  2.62
  5.36
  3.29
propyl acetate
3
  5.98
  5.29
  8.03
  7.44
*
*
p-xylene
2
10.98
  9.82
14.29
14.17
22.99
18.69
pyridine
2
12.64
11.24
  9.60
  8.57
15.40
16.45
sulfolane
2
47.62
43.31
34.02
28.90
36.76
48.67
tert-butylmethyl ether
3
  1.94
  1.82
  3.50
  3.59
  7.52
  5.73
tetrahydrofuran
3
  3.63
  3.19
  5.12
  4.90
  9.81
  9.48
tetralin
2
25.12
23.48
27.49
27.44
37.27
31.72
toluene
2
  7.86
  6.91
  9.80
  9.66
17.36
14.00
1,1-diethoxypropane
—
  5.42
  4.84
11.39
11.38
19.82
15.08
2,2-dimethoxypropane
—
  3.11
  2.79
  5.48
  5.55
11.37
  8.67
2-chloropropane
—
  1.96
  1.82
  2.67
  2.66
  5.20
  4.61
2-methylpentane
—
  1.58
  1.52
  3.22
  3.56
  7.72
  4.32
acetaldehyde
—
  2.05
  1.85
  1.86
  1.84
  3.14
  3.90
chloroethane
—
  1.83
  1.71
  2.14
  2.10
  3.97
  3.55
chloromethane
—
  1.63
  1.55
  1.70
  1.70
  3.01
  2.73
ethylene oxide
—
  2.05
  1.86
  1.89
  2.02
  3.59
  3.92
formaldehyde
—
  2.25
  1.57
  1.68
  1.58
  2.66
  2.59
isoamyl acetate
—
10.51
  9.43
14.84
14.18
22.80
22.62
isooctane
—
  1.85
  1.75
  5.84
  6.59
13.66
  8.07
isopropyl ether
—
  1.86
  1.76
  4.03
  4.23
  9.03
  5.83
methyl cyclopentane
—
  1.91
  1.79
  4.50
  4.93
10.41
  5.81
methyl isopropyl ketone
—
  4.93
  4.29
  6.58
  5.69
11.04
14.47
methylal
—
  2.26
  2.06
  2.84
  2.82
  5.65
  5.09
trichloroethene
—
  6.50
  5.70
  7.07
  7.05
13.58
  9.75
water
—
  8.24
  7.18
  1.74
  1.68
  2.75
  2.57
*not determined


Retention time data collected using the following conditions:

Stabilwax (G16)

 

Column dimensions:

30m x 0.25mm x 0.5µm df

Phase ratio:

125

Oven program:

40°C, hold 1 min., to 190°C @ 4°C/min., hold 15 min.

Carrier gas:

helium

Carrier flow (mL/min.):

1.2

Dead time (min.):

1.38 @ 45°C

  

Rtx-WAX (G16)

Column dimensions:

30m x 0.25mm x 0.5µm df

Phase ratio:

125

Oven program:

40°C, hold 1 min., to 190°C @ 4°C/min., hold 15 min.

Carrier gas:

helium

Carrier flow (mL/min.):

1.2

Dead time (min.):

1.40 @ 45°C

  

Rtx-1301 (G43)

Column dimensions:

30m x 0.25mm x 1.0µm df

Phase ratio:

63

Oven program:

40°C, hold 1 min., to 190°C @ 4°C/min., hold 15 min.

Carrier gas:

helium

Carrier flow (mL/min.):

1.2

Dead time (min.):

1.40 @ 45°C

  

Rxi-5ms (G27)

Column dimensions:

30m x 0.25mm x 1.0µm df

Phase ratio:

63

Oven program:

40°C, hold 1 min., to 190°C @ 4°C/min., hold 15 min.

Carrier gas:

helium

Carrier flow (mL/min.):

1.1

Dead time (min.):

1.49 @ 45°C

  

Rtx-1 (G1)

Column dimensions:

60m x 0.53mm x 3.00µm df

Phase ratio:

43

Oven program:

30°C, hold 4 min., to 220°C @ 4°C/min.

Carrier gas:

helium

Carrier flow (mL/min.):

6.3

Dead time (min.):

2.54 @ 35°C

  

Rtx-200

Column dimensions:

60m x 0.53mm x 3.00µm df

Phase ratio:

43

Oven program:

30°C, hold 4 min., to 220°C @ 4°C/min.

Carrier gas:

helium

Carrier flow (mL/min.):

7.8

Dead time (min.):

2.22 @ 35°C

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