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Fast Analysis of Alkylfurans by LPGC-MS

Featured Application: Alkylfurans on LPGC Rxi-624 Sil MS

  • 2.3x faster than conventional GC-MS analysis.
  • Reduces helium usage by 72% compared to conventional GC-MS methods. 
  • Rxi-624Sil MS kits are factory connected with a proven leak-free connector making LPGC as simple as a column change.

A known toxin in food products generated in heat or sterilization, alkylfurans are an important class of compounds in food safety testing. These potential carcinogens are a global health concern and are commonly analyzed by static headspace or solid phase microextraction coupled with GC-MS. Laboratories analyzing for alkylfurans in food products often work with a high volume of diverse sample types that can make conventional GC-MS analysis costly and time-consuming. Additionally, there are several critical separations that can be troublesome and difficult to resolve. 

We developed a novel method to significantly cut down on extended analysis times with our new Rxi-624Sil MS low-pressure GC (LPGC) column kit. This unique column setup lowers the pressure inside the column, allowing for drastic reductions in analysis time and helium usage. Analyzing eight common alkylfurans on the LPGC Rxi-624 Sil MS kit (cat.# 11804), analysis time was reduced from ~12 minutes to ~5 minutes compared to the conventional GC method (see Figure 1 below). Additionally, good resolution was achieved for the critical separations of 2-methylfuran and 3-methylfuran (Peak 2 and Peak 3) along with 2,3-dimethylfuran and 2,5-dimethylfuran (Peak 5 and Peak 6).

A simple column change can lead to significant gains for food safety labs analyzing a high volume of samples. Utilizing a LPGC column significantly reduces analysis time allowing for increased sample throughput while conserving helium. Each of our factory-coupled LPGC kits are individually tested, so you can have the assurance of a leak-free connection. To learn more about the LPGC technique, visit

Figure 1: Fast GC-MS Analysis of Alkylfurans on LPGC Rxi-624Sil MS