Improving Liquid Chromatography (LC) Column Connections

A good connection is necessary for trouble-free chromatography. Connecting incompatible fittings from different manufacturers can result in leaks, poor peak shape, and increased void volume (Figure 1). Each type of end-fitting has a unique seat depth or style. Generally, Restek, Valco, Parker, and Upchurch Scientific fittings are interchangeable; whereas Waters, SSI, Rheodyne, and Gasukura fittings are not (Figure 2).

Our wrenchless universal 10-32 PEEK column connector (cat.# 25015) can be used with any style of end fitting, and all 1/16-inch tubing. It is reusable and will adjust to any seat, depth, or style.

Figure 1: Incompatible fittings create problems

Figure 2: Fitting styles differ among various manufacturers.