Optimizing Splitless GC Injections

Author(s): Linx Waclaski
Restek Corporation

Published By: LCGC’s The Column

Issue: Volume 8, Issue 14

Year of Publication: 2018

Link: https://www.chromatographyonline.com/optimizing-splitless-gc-injections-0

Abstract: Splitless injections are sometimes necessary for trace analyses, where the analyst hopes to recover 100% of the analytes that are injected. Unfortunately, splitless injections can be challenging, and using an imperfect method can lead to loss of analytes and poor peak shapes. The choice of inlet liner can have an impact on the data and one must consider the effects of geometry, packing, deactivation, and volume on introduction of analytes into the system. Other important inlet parameters to consider include inlet temperature, splitless hold time, and initial oven temperature.