Resource Hub / Technical Literature Library / Potency Analysis of Cannabis and Derivative Products Part 2

Potency Analysis of Cannabis and Derivative Products: Part 2

Author: Rebecca Stevens

Restek Corporation

Published By: Cannabis Industry Journal

Year of Publication: 2016



For potency analysis via HPLC, grinding/homogenization and alcohol extraction is a common sample prep technique for dried flower and extracts.

As mentioned in Part 1, the physiological effects of cannabis are mediated by a group of structurally related organic compounds known as cannabinoids. The cannabinoids are biosynthetically produced by a growing cannabis plant and Figure 1 details the biosynthetic pathways leading to some of the most important cannabinoids in plant material.

The analytical measurement of cannabinoids is important to ensure the safety and quality of cannabis as well as its extracts and edible formulations. Total cannabinoid levels can vary significantly between different cultivars and batches, from about 5% up to 20% or more by dry weight. Information on cannabinoid profiles can be used to tailor cultivars for specific effects and allows end users to select an appropriate dose.