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Raptor C18: Raptor Speed, Efficiency, and Ruggedness—in C18


With Raptor LC columns, Restek chemists became the first to combine the speed of 2.7 and 5 μm superficially porous particles (also known as SPP or “core-shell” particles) with the resolution of highly selective USLC technology, improving separations and speeding up analysis times with standard HPLC instruments. Raptor then evolved to bring that same improved speed, efficiency, and selectivity to UHPLC analyses by offering 1.8 μm particle columns. Learn more about Raptor LC columns at

Even though every LC lab has a cache of C18s, not all C18s are created equal. Because the chemistry tends to be similar, the silica support that carries this ubiquitous octadecylsilane phase becomes vitally important. When you need a general-purpose LC column, don’t just grab any C18. Choose the speed, efficiency, and long-lasting ruggedness of the Raptor C18 SPP LC column.

The traditional end-capped Raptor C18 offers the highest hydrophobic retention of any Raptor phase, and it is compatible with a wide range of mobile phases from moderately acidic to neutral (pH 2–8). Whether for food safety, environmental, or bioanalytical analyses, this phase offers consistently excellent data quality in less time across myriad reversed-phase applications, matrices, and compound classes.

Column Description:


Stationary Phase Category:

C18, octadecylsilane (L1)

Ligand Type:

End-capped C18


1.8 μm, 2.7 μm, or 5 μm superficially porous particle (SPP or “core-shell” particle) silica

Pore Size:

90 Å

Surface Area:

125 m2/g (1.8 μm),
130 m2/g (2.7 μm),
or 100 m2/g (5 μm)


Column Interaction Profile:


Defining Solute Interactions:

  • Dispersion

Recommended Usage:

pH Range: 2.0–8.0
Maximum Temperature: 80 °C
Maximum Pressure: 1034 bar/15,000 psi* (1.8 μm),
600 bar/8700 psi (2.7 μm); 400 bar/5800 psi (5 μm)
* For maximum lifetime, recommended maximum pressure for 1.8 μm particles is 830 bar/12,000 psi.


  • Compatible with moderately acidic to neutral mobile phases (pH 2–8).
  • Excellent data quality in food, environmental, bioanalytical, and other applications.

Switch to a C18 when:

  • You need a general-purpose column for reversed-phase chromatography.
  • You need to increase retention of hydrophobic compounds.

Solute Retention Profile:


Target Analyte Structures:

  • Hydrocarbons

Target Analyte Functionalities:

  • Hydrophobic compounds


Raptor C18 Performance: Speed, Efficiency, and Ruggedness in Action

Raptor C18 columns provide outstanding dependability and data quality with high efficiency and peak symmetry, and they are built to exacting specifications that make your columns exceptionally consistent and improve their lifetime. To lower costs and improve profitability, you need columns to last longer, data to be reproducible, and existing HPLC instrumentation to run faster. Get there with the only general-purpose C18 that gives you Selectivity Accelerated.

Figure 1: Comparing 50 mm x 2.1 mm sub-2 μm C18 columns, Raptor columns maintain reliable performance past 1000 injections, consistently matching or beating the competition.

Expect consistently high performance over 1000 injections


Figure 2: Raptor columns' stringent quality control (QC) specifications guarantee outstanding peak shape, even with active compounds, for superior data quality.

Outstanding peak shapes for top-notch data



Figure 3: Lot-to-lot reproducibility is the key to keeping your productivity high and budget low. You can expect the same exceptional performance from every Raptor C18 column you purchase.

Lot-to-lot reproducibility for fast, reliable results every time



Boost Your Productivity with Raptor C18 LC Columns

When developing an assay, it is important to consider how productive your method will be. Because superficially porous, or “core-shell,” particles are well known for very high efficiency with minimal backpressure, they are ideal for decreasing analysis time (Figure 4). With its general-purpose applicability and SPP core-shell particles, the Raptor C18 column lets you quickly develop faster methods, thereby boosting your productivity.

Figure 4: SPP particles, like those in the Raptor C18 column, are one important step towards total method optimization.



Figure 5: Raptor C18s offer exceptional peak symmetry and efficiency for high sensitivity—making them ideal for high-throughput LC-MS/MS.



Your Go-To LC Column for Fast and Dependable Analyses on Any Instrument

C18 columns are often a method developer’s first choice, not only for their trusted performance but also for their effectiveness with many types of compound and instrument. The Raptor C18 was designed to build on that foundation, offering usability, peak symmetry, efficiency, and dependability—with the unmatched reproducibility, speed, and reliability of a Raptor SPP LC column. Whether you are doing environmental, food safety, or bioanalytical work (Figures 5 and 6), you will finish your work faster if you choose the right column the first time. For general-purpose applications, the Raptor C18 is your best first choice.

Figure 6: Get the data quality and short analysis times you need with Raptor C18 columns, as shown here with perfluorinated compounds (PFCs).



The Perfect Complement to High-Throughput Mass Spec

Fast LC-MS/MS screens with their exacting retention time windows place severe demands on your LC column. The Raptor C18 can easily and dependably handle mass spec analysis of closely related compounds like macrolide antibiotics, which are widely used in human and veterinary medicine (Figure 7). Because it’s a Raptor LC column, this C18 provides the reproducibility and consistent retention required for precise MRM analyses.

Figure 7: Confidently analyze closely eluting compounds, like macrolide antibiotics in this bioanalytical analysis, by LC-MS/MS.



Improve Resolution on Your Current Methods

To quickly improve your data quality, add a Raptor C18 SPP column to your existing C18 methods. As exemplified in Figure 8 with EPA method TO-11A, which determines toxic compounds in ambient air, the Raptor C18 offers better peak separation than a traditional fully porous C18.

Figure 8: Make a good method even better with improved resolution by switching your traditional fully porous C18 for a Raptor C18 column.


Experience Selectivity Accelerated. Order the Raptor C18 LC column today.