Raptor C18: Raptor Speed, Efficiency, and Ruggedness—in C18
With Raptor LC columns, Restek chemists became the first to combine the speed of 2.7 and 5 μm superficially porous particles (also known as SPP or “core-shell” particles) with the resolution of highly selective USLC technology, improving separations and speeding up analysis times with standard HPLC instruments. Raptor then evolved to bring that same improved speed, efficiency, and selectivity to UHPLC analyses by offering 1.8 μm particle columns. Learn more about Raptor LC columns at www.restek.com/raptor
Even though every LC lab has a cache of C18s, not all C18s are created equal. Because the chemistry tends to be similar, the silica support that carries this ubiquitous octadecylsilane phase becomes vitally important. When you need a general-purpose LC column, don’t just grab any C18. Choose the speed, efficiency, and long-lasting ruggedness of the Raptor C18 SPP LC column.
The traditional end-capped Raptor C18 offers the highest hydrophobic retention of any Raptor phase, and it is compatible with a wide range of mobile phases from moderately acidic to neutral (pH 2–8). Whether for food safety, environmental, or bioanalytical analyses, this phase offers consistently excellent data quality in less time across myriad reversed-phase applications, matrices, and compound classes.
Column Interaction Profile:
Defining Solute Interactions:
pH Range: 2.0–8.0
Switch to a C18 when:
Solute Retention Profile:
Target Analyte Structures:
Target Analyte Functionalities:
Raptor C18 Performance: Speed, Efficiency, and Ruggedness in Action
Raptor C18 columns provide outstanding dependability and data quality with high efficiency and peak symmetry, and they are built to exacting specifications that make your columns exceptionally consistent and improve their lifetime. To lower costs and improve profitability, you need columns to last longer, data to be reproducible, and existing HPLC instrumentation to run faster. Get there with the only general-purpose C18 that gives you Selectivity Accelerated.
Figure 1: Comparing 50 mm x 2.1 mm sub-2 μm C18 columns, Raptor columns maintain reliable performance past 1000 injections, consistently matching or beating the competition.
Expect consistently high performance over 1000 injections
Boost Your Productivity with Raptor C18 LC Columns
When developing an assay, it is important to consider how productive your method will be. Because superficially porous, or “core-shell,” particles are well known for very high efficiency with minimal backpressure, they are ideal for decreasing analysis time (Figure 4). With its general-purpose applicability and SPP core-shell particles, the Raptor C18 column lets you quickly develop faster methods, thereby boosting your productivity.
Your Go-To LC Column for Fast and Dependable Analyses on Any Instrument
C18 columns are often a method developer’s first choice, not only for their trusted performance but also for their effectiveness with many types of compound and instrument. The Raptor C18 was designed to build on that foundation, offering usability, peak symmetry, efficiency, and dependability—with the unmatched reproducibility, speed, and reliability of a Raptor SPP LC column. Whether you are doing environmental, food safety, or bioanalytical work (Figures 5 and 6), you will finish your work faster if you choose the right column the first time. For general-purpose applications, the Raptor C18 is your best first choice.
The Perfect Complement to High-Throughput Mass Spec
Fast LC-MS/MS screens with their exacting retention time windows place severe demands on your LC column. The Raptor C18 can easily and dependably handle mass spec analysis of closely related compounds like macrolide antibiotics, which are widely used in human and veterinary medicine (Figure 7). Because it’s a Raptor LC column, this C18 provides the reproducibility and consistent retention required for precise MRM analyses.
Improve Resolution on Your Current Methods
To quickly improve your data quality, add a Raptor C18 SPP column to your existing C18 methods. As exemplified in Figure 8 with EPA method TO-11A, which determines toxic compounds in ambient air, the Raptor C18 offers better peak separation than a traditional fully porous C18.