Pure Chromatography
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Mesylate, Besylate, and Tosylate Genotoxic Impurities on Rxi-624Sil MS (extracted ion chromatograms)
| Peaks | tR (min) | Ions Monitored (m/z) | |
|---|---|---|---|
| 1. | Methyl methanesulfonate (MMS) | 5.043 | 79, 80, 95 |
| 2. | Isopropyl methanesulfonate (iPMS) | 6.010 | 59, 79, 123 |
| 3. | Diethyl sulfate (DES) | 6.357 | 111, 125, 139 |
| 4. | di-isopropyl sulfate (DPS) | 6.970 | 45, 87, 167 |
| 5. | dibutyl sulfate (DBS) | 9.260 | 29, 41, 56 |
| 6. | Methyl benzenesulfonate (MBS) | 9.463 | 77, 141, 172 |
| 7. | Ethyl benzenesulfonate (EBS) | 9.883 | 77, 141, 186 |
| 8. | Methyl toluenesulfonate (MTS) | 10.337 | 91, 155, 186 |
| 9. | Ethyl toluenesulfonate (ETS) | 10.713 | 91, 155, 200 |
| 10. | n-propyl toluenesulfonate (nPTS) | 10.827 | 91, 155, 172 |
| 11. | n-butyl benzenesulfonate (nBBS) | 11.07 | 77, 141, 159 |
| 12. | isopropyl p-toluenesulfonate (iPTS) | 11.240 | 91, 155, 172 |
| 13. | p-toluenesulfonic acid n-butyl ester (nBTS) | 11.823 | 91, 155, 173 |
* ortho isomer of ETS
GC_PH1165
| Column | Rxi-624Sil MS, 20 m, 0.18 mm ID, 1.00 µm (cat.# 13865) |
| Sample | |
| Diluent: | 90:10 acetonitrile:water |
| Conc.: | 500 ng/mL |
| Injection | |
| Inj. Vol.: | 1 µL splitless (hold 0.5 min) |
| Liner: | 3.5mm Single Gooseneck Liner with wool placed 3cm from top (middle) (cat.# 22286) |
| Inj. Temp.: | 220 °C |
| Purge Flow: | 3 mL/min |
| Oven | |
| Oven Temp.: | 80 °C (hold 2 min) to 300 °C at 20 °C/min (hold 5 min) |
| Carrier Gas | He, constant flow |
| Linear Velocity: | 45 cm/sec |
| Detector | MS |
| Mode: | SIM |
| Transfer Line Temp.: | 280 °C |
| Analyzer Type: | Quadrupole |
| Source Temp.: | 280 °C |
| Solvent Delay Time: | 4 min |
| Ionization Mode: | EI |
| Instrument | Shimadzu 2010 GC & QP2010+ MS |
| Acknowledgement | In collaboration with Merck and Company |
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Copyright © 2019 Restek Corporation. All rights reserved.
A Company of Owners
Cookies allow for a variety of features that make your visit to Restek more enjoyable. By using this website, you agree to the use of cookies in accordance with our guidelines. For more information, see our privacy policy.