Pure Chromatography
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Analgesics and Non-Steroidal Anti-Inflamatory Drugs (NSAID) on Raptor Biphenyl by LC-MS/MS
| Peaks | tR (min) | Conc. (ng/mL) | Precursor Ion | Product Ion | Product Ion | ESI Polarity | |
|---|---|---|---|---|---|---|---|
| 1. | Acetaminophen | 1.19 | 100 | 152.2 | 93.0 | 65.0 | Positive |
| 2. | Tenoxicam | 2.26 | 100 | 338.1 | 121.0 | 95.0 | Positive |
| 3. | Etoricoxib | 2.84 | 100 | 359.2 | 280.0 | 279.2 | Positive |
| 4. | Lornoxicam | 3.08 | 200 | 373.1 | 121.1 | 95.0 | Positive |
| 5. | Ketorolac | 3.22 | 100 | 256.1 | 104.9 | 77.0 | Positive |
| 6. | Piroxicam | 3.26 | 100 | 332.1 | 95.2 | 78.1 | Positive |
| 7. | Loxoprofen | 3.41 | 100 | 245.0 | 83.2 | 80.9 | Negative |
| 8. | Tolmetin | 3.64 | 100 | 258.1 | 119.1 | 91.0 | Positive |
| 9. | Sulindac | 3.83 | 100 | 357.2 | 233.1 | 248.0 | Positive |
| 10. | Ketoprofen | 4.00 | 100 | 253.0 | 209.0 | -- | Negative |
| 11. | Naproxen | 4.05 | 200 | 229.0 | 168.9 | 184.9 | Negative |
| 12. | Salsalate | 4.05 | 100 | 256.8 | 136.8 | 92.9 | Negative |
| 13. | Meloxicam | 4.22 | 100 | 352.1 | 115.0 | 141.0 | Positive |
| 14. | Etodolac | 4.80 | 100 | 286.0 | 241.9 | 212.0 | Negative |
| 15. | Fenoprofen | 4.84 | 200 | 240.9 | 92.8 | -- | Negative |
| 16. | Oxaprozin | 4.86 | 200 | 292.0 | 219.8 | 102.0 | Negative |
| 17. | Ibuprofen | 4.92 | 200 | 205.0 | 160.9 | -- | Negative |
| 18. | Flurbiprofen | 4.99 | 100 | 243.0 | 199.0 | 196.8 | Negative |
| 19. | Parecoxib | 5.20 | 200 | 371.2 | 234.0 | 165.1 | Positive |
| 20. | Nabumetone | 5.23 | 100 | 229.1 | 171.1 | 128.1 | Positive |
| 21. | Diclofenac | 5.46 | 100 | 293.9 | 249.8 | -- | Negative |
| 22. | Indomethacin | 5.60 | 100 | 356.0 | 311.8 | 296.9 | Negative |
| 23. | Flufenamic acid | 5.75 | 100 | 279.9 | 236.1 | 176.2 | Negative |
| 24. | Celecoxib | 5.90 | 200 | 382.2 | 362.0 | 300.1 | Positive |
| 25. | Mefenamic acid | 5.91 | 100 | 242.1 | 224.1 | -- | Positive |
| 26. | Tolfenamic acid | 6.21 | 100 | 259.9 | 215.8 | -- | Negative |
| 27. | Meclofenamic acid | 6.29 | 200 | 293.9 | 257.8 | 177.7 | Negative |
LC_CF0620
| Column | Raptor Biphenyl (cat.# 9309A12) | ||||||||||||||||||||||||
| Dimensions: | 100 mm x 2.1 mm ID | ||||||||||||||||||||||||
| Particle Size: | 2.7 µm | ||||||||||||||||||||||||
| Guard Column: | Raptor Biphenyl EXP guard column cartridge 5 mm, 2.1 mm ID, 2.7 µm (cat.# 9309A0252) | ||||||||||||||||||||||||
| Temp.: | 30 °C | ||||||||||||||||||||||||
| Sample | |||||||||||||||||||||||||
| Diluent: | Water | ||||||||||||||||||||||||
| Inj. Vol.: | 5 µL | ||||||||||||||||||||||||
| Mobile Phase | |||||||||||||||||||||||||
| A: | Water + 0.1% formic acid + 5 mM ammonium formate | ||||||||||||||||||||||||
| B: | (95:5) Acetonitrile:water + 0.1% formic acid + 5 mM ammonium formate | ||||||||||||||||||||||||
| |||||||||||||||||||||||||
| Detector | MS/MS | ||||||||||||||||||||||||
| Ion Mode: | ESI+/ESI- | ||||||||||||||||||||||||
| Mode: | Scheduled MRM | ||||||||||||||||||||||||
| Instrument | UHPLC | ||||||||||||||||||||||||
| Notes | 1. Positive and negative polarity was collected simultaneously from a single injection. 2. Oxaprozin displays enhanced sensitivity using positive polarity. |
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Restek Corporation, U.S., 110 Benner Circle, Bellefonte, PA 16823
Copyright © 2021 Restek Corporation. All rights reserved.
A Company of Owners
Cookies allow for a variety of features that make your visit to Restek more enjoyable. By using this website, you agree to the use of cookies in accordance with our guidelines. For more information, see our privacy policy.