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When Do We Need Sub-2-µm Superficially Porous Particles for Liquid Chromatography Separations?

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Authors: David S. Bell, Landon Wiest, Shun-Hsin Liang, Dan Li

Restek Corporation

Published By: LCGC North America

Year of Publication: July 2018

Volume, Issue: Volume 36, Issue 7

Link: https://www.chromatographyonline.com/view/when-do-we-need-sub-2-m-superficially-porous-particles-liquid-chromatography-separations

Abstract: The use of superficially porous particles (SPPs) for modern high performance liquid chromatography (HPLC) is now very common. Initially, SPPs rose as an alternative to sub-2-µm fully porous particles (FPPs). In recent years, many column manufacturers have developed 2-µm and smaller SPP-based products. This article investigates the practical utility of these smaller SPP designs.