Class 1 Residual Solvents for USP <467> Water-Soluble Articles on Rxi-624Sil MS

* DMSO interference

Oven
Column	Rxi-624Sil MS, 30 m, 0.32 mm ID, 1.80 µm (cat.# 13870)
Standard/Sample	Residual Solvents - Class 1 (cat.# 36279)
Diluent:	water
Injection	headspace-loop split (split ratio 5:1)
Liner:	1mm Split (cat.# 20972)
Headspace-Loop
Inj. Port Temp.:	140 °C
Instrument:	Tekmar HT3
Inj. Time:	1 min
Transfer Line Temp.:	110 °C
Valve Oven Temp.:	110 °C
Sample Temp.:	80 °C
Sample Equil. Time:	60 min
Vial Pressure:	10 psi
Pressurize Time:	0.5 min
Pressure Equilibration Time:	0.05 min
Loop Pressure:	5 psi
Loop Fill Time:	0.1 min
Oven Temp.:	40 °C (hold 20 min) to 240 °C at 10 °C/min (hold 20 min)
Carrier Gas	He, constant flow
Linear Velocity:	35 cm/sec
Dead Time:	1.45 min @ 40 °C

Detector	FID @ 250 °C
Data Rate:	5 Hz
Instrument	Agilent/HP6890 GC
Notes	Columns were run under identical conditions.
Acknowledgement	Teledyne Tekmar

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