LC-MS/MS Analysis of 58 Antipsychotics and Antidepressants in Human Urine

Published By: Restek Corporation

Year of Publication: 2019

Link: https://www.restek.com/Technical-Resources/Technical-Library/Clinical-Forensic-Toxicology/cft_CFSS3051-UNV

Abstract:

Simultaneous measurement of 58 antipsychotic and antidepressant drugs in human urine can be achieved with a simple sample preparation procedure and a fast 5.5-minute LC-MS/MS analysis on a Raptor Biphenyl column. This method provides accurate, high-throughput determinations and is suitable for both clinical and forensic monitoring.

Robust Analysis of Fatty Acids in Milk: An Independent Lifetime Evaluation of Rt-2560 GC Columns

Published By: Restek Corporation

Year of Publication: 2019

Link: https://www.restek.com/Technical-Resources/Technical-Library/Foods-Flavors-Fragrances/fff_FFAR3047-UNV

Abstract:

The analysis of fatty acids in milk fat is an important test and this challenging matrix was used by Eurofins Analytik GmbH to evaluate the stability of Rt-2560 columns. Consistent retention times and separations were achieved even after 225 injections, demonstrating the column’s robust performance.

Can Nonmatching Mycotoxin SIDA Internal Standards Be Used for Stable Isotope Dilution Assay Calibration?

Published By: Restek Corporation

Year of Publication: 2019

Link: https://www.restek.com/Technical-Resources/Technical-Library/Foods-Flavors-Fragrances/fff_FFAR3036-UNV

Abstract:

Stable isotope dilution assay (SIDA) is a calibration technique that can be used to offset matrix effects. However, care must be given to choosing appropriate internal standards. This article demonstrates the importance of using a labeled internal standard that matches the target analyte for mycotoxins analysis.

Faster GC-MS Analysis of 3-MCPD and Glycidyl Esters in Edible Oils

Published By: Restek Corporation

Year of Publication: 2019

Link: https://www.restek.com/Technical-Resources/Technical-Library/Foods-Flavors-Fragrances/fff_FFSS3027-UNV

Abstract:

The analysis of 3-MCPD and glycidyl esters using AOCS Cd 29c-13 is time consuming and exposes the GC-MS to harsh derivatization reagents that can limit column lifetime and increase maintenance costs. Here, we optimized the method using split injection, resulting in a time savings of 8 minutes, less damage from derivatization reagents, and the flexibility to use either PTV or split/splitless inlets.

Comparison of extraction techniques for polycyclic aromatic hydrocarbons from lichen biomonitors

Author(s): Leandri Van der Wat and Patricia B. C. Forbes
Department of Chemistry, University of Pretoria, Hatfield, South Africa

Published By: Environmental Science and Pollution Research

Issue: 26

Year of Publication: 2019

Link: https://link.springer.com/article/10.1007%2Fs11356-019-04587-3

Abstract: Lichens are useful biomonitors for atmospheric polycyclic aromatic hydrocarbons (PAHs). Different sample preparation techniques were explored in this regard, including ultrasound-assisted solvent extraction, microwave-assisted extraction, Soxhlet, and the quick, easy, cheap, effective, rugged, and safe (QuEChERS) technique. It was found that a QuEChERS technique using hexane:acetone (1:1, v/v), never reported before for application to lichens, provided the best recoveries of internal standards, the highest total peak area for all PAHs of interest, and %RSDs comparable with the other preparation techniques tested. The optimized sample preparation technique was found to be a comparatively fast method (45 min), with good recoveries (96%), using less solvents and minimal energy consumption. Strong matrix effects were found: both strong enhancement (for the lighter PAHs) and strong suppression (for the heavier PAHs). The use of matrix-matched standards is thus imperative for the accurate determination of PAH concentrations in the lichen samples.

Acknowledgment(s): Restek Corporation and Wirsam Scientific are
thanked for their support of this research.

Evaluation of a Simple Method for Methylmalonic Acid Analysis in Human Plasma by LC-MS/MS

Author: Justin Steimling and Frances Carroll

Published By: Restek Corporation

Year of Publication: 2019

Link: https://www.restek.com/Technical-Resources/Technical-Library/Clinical-Forensic-Toxicology/cft_CFAN3010-UNV

Abstract:

A new LC-MS/MS method for methylmalonic acid (MMA) analysis was developed that provides complete chromatographic resolution from isobaric succinic acid in plasma samples. Excellent chromatographic results were obtained from the direct injection of a protein crash sample supernatant onto a Force C18 column, providing a much simpler sample preparation compared to typical methods.

Resprep EPH Fractionation SPE Cartridges: Now Available in a 2 g Format

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Restek Honored by Leading Science Publication

Of the thousands of reviews on SelectScience, Restek had the highest average rating in 2018

Restek President Bryan Wolcott accepting the SelectScience Reviewers’ Choice Award for
Analytical Science Company of the Year.

The reviews are in and Restek is on top.

Leading independent science publisher SelectScience presented Restek with its Reviewers’ Choice Award for Analytical Science Company of the Year, in recognition of the high ratings and positive feedback it received from customers leaving laboratory product reviews on its influential website.

The award was presented to Restek President Bryan Wolcott by SelectScience Editor-in-Chief Kerry Parker.

“These awards are truly unique within the science industry—the only awards where scientists themselves decide who should win,” Parker said.

Winners and nominees of the annual Scientists’ Choice Awards were celebrated during a glitzy SelectScience party on March 21 at the Pittcon 2019 International Conference and Expo in Philadelphia.

“It’s an honor to be among the winners and nominees who are making waves in the fields of general lab, spectroscopy, and separations,” Wolcott said. “We work hard every day to create products that meet the high expectations of our customers. Thank you SelectScience and the scientific community for recognizing our efforts.”

Of the thousands of reviews by users on SelectScience, the award recognized Restek for having the highest average rating in 2018.

This is the second award Restek received this year. In January, Global distributor Avantor presented Restek with its Platinum Level Achievement Award for Operational Excellence to recognize Restek’s commitment to enrichment, cooperation, quality assurance, and shipping performance.