A Breakthrough for Rapid Screening: Be Among the First to Experiment with Restek Coated Blade Spray Technology!

Restek coated blade spray (CBS) technology accelerates rapid-screening analyses to a new level of efficiency and speed. Based on strong sample extraction and ionization foundations, CBS technology bridges the gap between sample preparation and MS/MS analysis by providing a product that can go directly from the sample to the mass spectrometer. Rapid-screening workflows that once required complex, distinct, sample preparation methods and chromatographic separations are reduced to a few simple steps. And your most powerful analytical tool—chromatography—is reserved for only select samples that need additional analysis.

As a technology on the cutting edge of commercialization, coated blade spray will continue to evolve, but for laboratories interested in evaluating how coated blade spray can revolutionize their analytical workflows, Restek is proud to present the first in a long line of direct-to-MS products to come: the coated CB-HLB blade. A precision-made, stainless-steel blade supports a specially prepared coating of hydrophilic-lipophilic balanced (HLB) sorbent, making the CB-HLB a finely tuned sample preparation product.

Ionization interfaces and a completely commercialized solution are under development and coming soon, but if your lab performs screening analyses, or if you are interested in finding out more about coated blade spray technology from Restek, sign up at


Once you do, we will begin sending you periodic updates on new CBS developments and may also contact you to further discuss coated blade spray or to answer any questions you may have.

Target Mycotoxins in Cannabis with Restek’s New Ochratoxin A & Aflatoxins Standards

Mycotoxins are toxic secondary metabolite compounds produced by mold or fungi. Due to the toxicity of certain mycotoxins that can be found on cannabis plants, there is a growing need to detect their presence in both raw plant materials and finished cannabis products.

Restek now offers two new mycotoxin certified reference materials (CRMs): Ochratoxin A (cat.# 34122) and Aflatoxins (B1, B2, G1, G2) (cat.# 34121).

These new reference standards enable labs to expand their cannabis analyses with a Restek solution when coupled with our high-throughput Raptor ARC-18 (cat.# 9314A12) LC column.

For mycotoxins and other reference standards, Raptor LC columns, sample preparation products, and the expert consultation your cannabis lab needs, turn to www.restek.com/cannabis

Get a Quicker Cleanup: Resprep SLE Cartridges and 96-Well Plates

Dilute-and-shoot is only effective when you are working with relatively clean matrices—complex biological samples, such as whole blood, require a cleanup step or your results may be inaccurate. But, if your sample matrix does not require the intensive cleanup power of SPE or liquid-liquid extraction, why spend time and resources on a complex procedure? For many compounds, excellent analytical results can be obtained with a quick and easy SLE cleanup. New Resprep SLE cartridges and 96-well plates effectively remove matrix components, such as proteins, phospholipids, and salts, in three simple steps: just load, wait 5 minutes, then elute. Suitable for a wide range of matrices and analytes, Resprep SLE cleanup is a quick, efficient, and fully automatable sample preparation solution.
Get details at www.restek.com/ResprepSLE

Separate a Wide Variety of Polar Analytes with New Raptor Polar X Columns

Analyzing polar compounds using liquid chromatography has historically been a challenge. Poor retention and peak shape, complex mobile phases that may not be MS-friendly, long equilibration times, low sensitivity, and sample derivatization are all complications that reduce lab efficiency and productivity. However, new Raptor Polar X columns reliably retain and efficiently separate a broad range of polar analytes using a unique stationary phase that balances two retention mechanisms: HILIC and ion exchange. This hybrid phase is ideal for analyzing acidic, basic, and neutral polar compounds without time-consuming derivatization or complex ion pairing, and it is especially compatible with mass spectrometry. Easy changes to mobile phase conditions allow analysts to switch between modes and selectively tune retention for the compounds of interest without needing long equilibration times. Simplify the analysis of polar compounds with the resolving power of Raptor Polar X columns from Restek.

Learn more about Raptor Polar X columns at www.restek.com/PolarX

About Raptor SPP LC Columns:
Restek chemists became the first to combine the speed of superficially porous particles (also known as SPP or “core-shell” particles) with the resolution of highly selective USLC technology. This new breed of chromatographic column allows you to more easily achieve peak separation and faster analysis times without expensive UHPLC instrumentation.

Learn more about Raptor LC columns at www.restek.com/raptor

Advance Your Analysis of Cannabis With Our New Cannabidivarinic Acid (CBDVA) Standard

Cannabidivarinic Acid (CBDVA) is a non-psychoactive cannabinoid reported to have anti-inflammatory properties. While its medicinal benefits are still being researched, quantifying this compound in cannabis samples is crucial for obtaining a true measurement of potency and chemovar identification. Restek now offers a new CBDVA certified reference material (CRM) to help labs advance their analysis of cannabis.

Restek’s new CBDVA standard is ideal for creating multipoint (5-point minimum suggested) calibration curves for LC analysis. With verified composition and stability, this prepared stock product eliminates the need for in-house standards preparation for greater convenience and lower labor requirements. As it’s excluded from U.S. DEA Controlled Substances Act (CSA) regulatory controls, no customer permits or licensing required to purchase within the U.S., and because it’s manufactured and QC tested in Restek’s ISO-accredited labs, this new CBDVA standard qualifies as a certified reference material (CRM) that satisfies your ISO requirements.

For CBDVA and other reference standards, Raptor LC columns, sample preparation products, and the expert consultation your cannabis lab needs, turn to www.restek.com/cannabis

Faster Trace-Level Analysis of Acrylamide in Drinking Water and Food

Now available in two column formats for optimal application-specific performance, Allure Acrylamide LC columns enable you to meet method requirements for food and drinking water quickly and easily. Unique column chemistry reliably separates acrylamide from matrix interferences, and our new format for large volume injection lets you reach sensitivity requirements without time-consuming SPE preconcentration. The new 150 x 3.0 mm column provides an optimized balance of larger capacity and MS-friendly flow rates for large volume injection of drinking water samples while the original 50 x 2.1 mm format delivers faster analysis times and fewer column changes for both food and drinking water when used with SPE sample preparation. Pair with Restek guard columns and analytical reference standards to ensure data quality even down to low ppt levels in sample matrix.

Developed to withstand 100% aqueous mobile phases and elute coextracted matrix components rather than strongly retaining them, Restek Allure Acrylamide guard and analytical columns deliver the same robust performance injection to injection and column to column. Our stringent manufacturing procedures and rigorous quality testing ensure that when it does come time to replace your Allure Acrylamide column, you will get the same great chromatographic performance with the new column that you relied on with the old one.


Simplify LC Method Migration with Pro EZLC Method Translator

Scaling down an existing LC method to a smaller column format can speed up run time, increase sample throughput, and reduce solvent use, but only if the LC conditions are also properly adjusted. Pro EZLC method translation software simplifies and streamlines this process by taking manual calculations and time-consuming lab work out of the way. Just input your current column dimensions and method conditions, then specify the dimensions of the new column you want to try; the Pro EZLC method translator will automatically generate new injection volumes and isocratic or gradient program conditions. In addition, the software displays speed gains, solvent savings, retention times, and critical pair resolution values so you can quickly assess results for different column options from your desk and be certain of method performance before starting in the lab.


New Resprep Polymeric SPE Offers an Alternative to Silica-Based Sorbents

Restek has expanded its line of Resprep solid phase extraction (SPE) products with the addition of polymeric sorbents, available in both cartridges for high loading capacity and 96-well plates for high throughput and automation.

Because Resprep polymeric SPE products feature a silica-free, bonded polymeric material, there are no unwanted secondary silica interactions, even with basic compounds. Their high surface area means a higher loading capacity compared to silica sorbents, and their stability over a wide pH range (0–14) means they won’t hydrolyze under extreme conditions. New Resprep polymeric SPE cartridges and 96-well plates are water-wettable, allowing for streamlined conditioning and equilibration steps to drastically reduce solvent usage and sample prep time. And they are not flow-rate dependent, so they maintain retention and capacity after conditioning, even if dried out from vacuum or positive pressure flows.

Resprep polymeric SPE products offer five distinct packings to choose from. Find them all, and the entire line of Resprep sample preparation products, at www.restek.com/resprep

Remove Both Phospholipids and Proteins in One Resprep PLR SPE Procedure

Simultaneously remove phospholipids and proteins in a single, simple procedure with new Resprep PLR (phospholipid removal) SPE products. Whole blood, serum, and plasma all contain proteins and phospholipids that can interfere with target analytes and hasten the need for instrument maintenance. It’s important to remove them from samples prior to analysis to avoid signal suppression, and Resprep PLR SPE cartridges or 96-well plates make this an easy task by combining protein precipitation and phospholipid removal in one sample preparation process. No analyte-specific method development is required because the same procedure can be used for samples containing acids, bases, or neutral compounds. In addition, effective removal of phospholipids and proteins from sample extracts reduces contamination, minimizing the frequency of instrument maintenance.


Eliminate Cross-Contamination with New Resprep Quick-Replace Vacuum Manifolds

Cross-contamination of samples run in series through typical SPE vacuum manifolds is a common problem for sample preparation labs. New Resprep Quick-Replace vacuum manifolds eliminate this risk because they contain a disposable valve liner that can be quickly and easily replaced between samples, ensuring a clean flow path for every extraction. In addition, the screw-type valve design provides precise, independent flow control of each SPE port. Resprep Quick-Replace vacuum manifolds are compatible with any standard male luer SPE cartridge and are available in 12- and 24-port models. The easily configurable rack system supports a wide variety of collection vessels and can be customized to accommodate vessel size.