Optimizing Splitless GC Injections

Author(s): Linx Waclaski
Restek Corporation

Published By: LCGC’s The Column

Issue: Volume 8, Issue 14

Year of Publication: 2018

Link: www.chromatographyonline.com/optimizing-splitless-gc-injections-0

Abstract: Splitless injections are sometimes necessary for trace analyses, where the analyst hopes to recover 100% of the analytes that are injected. Unfortunately, splitless injections can be challenging, and using an imperfect method can lead to loss of analytes and poor peak shapes. The choice of inlet liner can have an impact on the data and one must consider the effects of geometry, packing, deactivation, and volume on introduction of analytes into the system. Other important inlet parameters to consider include inlet temperature, splitless hold time, and initial oven temperature.

Join Restek at the Forensic Science Symposium Offered by Shimadzu

Wednesday, August 22, 2018, Shimadzu, 7100 Riverwood Drive, Columbia, MD 21046

Join Restek for a day of science at Shimadzu’s upcoming Forensic Science Symposium. This event will consist of scientific talks from collaborators at a crime laboratory, police department, medical examiner’s office, and key standards providers. These presentations will cover how GC-MS, LC-MS/MS, and the CLAM-2000 automated sample prep module for LC-MS are used in a forensic environment and how they are adapting to new challenges in today’s society. Below is a tentative schedule of events for the day.



9:00 a.m.              LC Column Selection for Forensic Applications, Frances Carroll, Restek Corporation

10:00 a.m.           Forensic Toxicology at the Federal Aviation Administration, Kacey Cliburn, Federal Aviation Administration

11:00 a.m.           Coffee/Tea Break

11:30 a.m.           Method Development and Validation of Various Designer Drugs Using LCMS-8060, Alex Giachetti, Miami Dade Medical Examiner

12:30 p.m.           Lunch

1:30 p.m.             Controlled Substances by GC-MS, TBD

2:30 p.m.             Developing Analytical Standards in a Rapidly Changing World, Sebastian Buchert, Cayman Chemical

3:30 p.m.             Coffee/Tea Break

4:00 p.m.             Automated Sample Preparation Using CLAM-2000 for Forensic Toxicology Applications, Josh Emory, Application Scientist, Shimadzu

5:00 p.m.             Wrap-Up


Please register by Friday, August 17 at https://conta.cc/2N06FYS

Lunch will be provided. Please specify any food allergies.