Liquid Chromatography: Pharmaceutical Applications (Chapter in Reference Module in Chemistry, Molecular Sciences and Chemical Engineering)

Author(s): D.M. Diehl1, David S. Bell2, Barbara Bojko3
1. Waters Corporation, 2. Restek Corporation, 3. Nicolaus Copernicus University

Published By: Elsevier

Year of Publication: 2018


Abstract: Liquid chromatography (LC) has been applied in the pharmaceutical industry almost from the inception of the technique. In this article, the overview of recent advancements in LC, like ultra-high-performance liquid chromatography and superficially porous particle (SPP) technology, which were adopted to analysis of pharmaceuticals can be found. The utilization of liquid chromatography during development and manufacturing stages of small molecule drugs is described. That includes aspects of purification, isolation, identification, and stability, among others. The article also considers application of modern LC strategies to analysis of the currently most emerging group of drugs, biopharmaceuticals. Finally, the LC approaches for metabolomics in drug discovery as well as pharmacometabolomics are discussed.

Comprehensive LC-MS/MS Analysis of 15 Bisphenols in 8 Minutes

Published By: Restek Corporation

Year of Publication: 2018


Abstract: The analysis of bisphenolic compounds that are used as alternatives to bisphenol A (BPA) is essential for monitoring exposure to and evaluating the safety of these emerging industrial chemicals. The LC-MS/MS method presented here provides excellent chromatographic peak shape and separation for an extensive list of BPA analogues in a fast, 8-minute analysis.

October Declared Employee Ownership Month in Pennsylvania

State Representative Kerry Benninghoff presented Restek with a resolution and praised the company on its success as an employee-owned business


State Representative Kerry Benninghoff (R-Bellefonte) presented Restek with a resolution on Oct. 3 declaring October “Employee Ownership Month” in Pennsylvania.

“It’s really an honor as someone who represents you in Harrisburg to assist you with the work you do. Rock on! The fact that you’re world-known is great bragging rights for your state representative and I’m happy to do that.” Rep. Benninghoff said.

Restek is owned by the employees through an Employee Stock Ownership Plan (ESOP). Since becoming 100% employee owned at the end of 2008, Restek has more than doubled in size and its stock value has grown 10-fold—to the direct benefit of its employees.

“We value seeing employee ownership extend to more and more companies throughout the state and creating more businesses like Restek where employees own the company, love working for it, take care of it, and take care of each other.” said Bryan Wolcott, Restek’s president and head coach.

There are currently more than 285 employee-owned companies in Pennsylvania, employing over 306,000 people. They include WaWa, Sheetz, Bradford White Water Heaters, and Voodoo Brewery. Nationally, 5,000 other companies have ESOPs, including Publix and New Belgian Beer.