Analysis of Food Samples Made Easy by Microextraction Technologies Directly Coupled to Mass Spectrometry

Author(s): Emanuela Gionfriddo1,2,3, German Augusto Gómez-Ríos4

1. Department of Chemistry and Biochemistry, College of Natural Sciences and Mathematics, The University of Toledo, 2. School of Green Chemistry and Engineering, The University of Toledo, 3. Dr. Nina McClelland Laboratory for Water Chemistry and Environmental Analysis, The University of Toledo, 4. Restek Corporation

Published By: The Journal of Mass Spectrometry

Year of Publication: 2020


Abstract: Because of the complexity and diversity of food matrices, their chemical analysis often entails several analytical challenges to attain accurate and reliable results, especially for multiresidue analysis and ultratrace quantification. Nonetheless, microextraction technology, such as solid‐phase microextraction (SPME), has revolutionized the concept of sample preparation for complex matrices because of its nonexhaustive, yet quantitative extraction approach and its amenability to coupling to multiple analytical platforms. In recent years, microextraction devices directly interfaced with mass spectrometry (MS) have redefined the analytical workflow by providing faster screening and quantitative methods for complex matrices. This review will discuss the latest developments in the field of food analysis by means of microextraction approaches directly coupled to MS. One key feature that differentiates SPME‐MS approaches from other ambient MS techniques is the use of matrix compatible extraction phases that prevent biofouling, which could drastically affect the ionization process and are still capable of selective extraction of the targeted analytes from the food matrix. Furthermore, the review examines the most significant applications of SPME‐MS for various ionization techniques such as direct analysis in real time, dielectric barrier desorption ionization, and some unique SPME geometries, for example, transmission mode SPME and coated blade spray, that facilitate the interface to MS instrumentation.

A Breakthrough for Rapid Screening: Be Among the First to Experiment with Restek Coated Blade Spray Technology!

Restek coated blade spray (CBS) technology accelerates rapid-screening analyses to a new level of efficiency and speed. Based on strong sample extraction and ionization foundations, CBS technology bridges the gap between sample preparation and MS/MS analysis by providing a product that can go directly from the sample to the mass spectrometer. Rapid-screening workflows that once required complex, distinct, sample preparation methods and chromatographic separations are reduced to a few simple steps. And your most powerful analytical tool—chromatography—is reserved for only select samples that need additional analysis.

As a technology on the cutting edge of commercialization, coated blade spray will continue to evolve, but for laboratories interested in evaluating how coated blade spray can revolutionize their analytical workflows, Restek is proud to present the first in a long line of direct-to-MS products to come: the coated CB-HLB blade. A precision-made, stainless-steel blade supports a specially prepared coating of hydrophilic-lipophilic balanced (HLB) sorbent, making the CB-HLB a finely tuned sample preparation product.

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Restek Is Presenting at NACRW 2020 Webinar

Though NACRW 2020 can’t be live and in-person this year, Restek is pleased to be part of its four-part webinar series.

Our own Joe Konschnik will be presenting the third webinar on “Unlocking the Mystery of Pesticides CRM Stability for Food Analysis,” on 13 October 2020, Tuesday, at 10:00 a.m. and 2:00 p.m., EDT.

Joe will be discussing how to properly handle and store pesticide CRMs to help ensure stability for food analysis. More information on Joe’s webinar is listed below. Additional NACRW webinars feature Steven Lehotay discussing the QuEChERSER mega-method for analyzing pesticides, veterinary drugs, and environmental contaminants; Jens Anderson explaining an alternative practice and procedure for QA/QC and metrology; and Jo Marie Cook presenting a best practice guide for reference materials used in trace-level analysis.

To learn more about the NACRW 2020 webinars, visit the site at



13 October 2020 Thursday, at 10:00 a.m. and 2:00 p.m. EDT

Unlocking the Mystery of Pesticides CRM Stability for Food Analysis

Joe Konschnik (presenter), Jason Fisher, Landon Wiest, Jana Rousova Hepner, Karen Risha

There is a growing global need for pesticide residues testing in a wide variety of food commodities. In response to this need, testing laboratories must develop versatile analytical methods and workflows in order to produce scientifically sound results which ensure the safety of our food. One of the many challenges faced by food chemists is acquiring suitable pesticide certified reference materials (CRMs) to calibrate analytical equipment, monitor method performance and confirm the identity and concentration of hundreds of pesticide residues in food samples. Questions regarding the stability of pesticide CRMs abound among users and there’s a need to educate and inform the community. CRM producers invest considerable resources to ensure the stability of their products. The authors will present proper CRM handling and storage practices as guidance to ensure stability based on the results of several multiresidue pesticide stability studies. The results of three pesticide mix stability studies will be shown demonstrating what can be expected after pesticide mix ampuls are opened and stored for use, and also when mixed together for routine LC-MS/MS and GC-MS/MS laboratory analysis.