When Do We Need Sub2m Superficially Porous Particles for Liquid Chromatography Separations

Author(s): David Bell, Landon Wiest, Shun-Hsin Liang, Dan Li
Restek Corporation

Published By: LCGC Asia Pacific

Issue: Volume 21, Issue 3

Year of Publication: 2018

Link: http://www.chromatographyonline.com/when-do-we-need-sub2m-superficially-porous-particles-liquid-chromatography-separations

Abstract: The use of superficially porous particles (SPPs) for modern high performance liquid chromatography (HPLC) is now very common. Initially, SPPs rose as an alternative to sub-2-µm fully porous particles (FPPs). In recent years, many column manufacturers have developed 2-µm and smaller SPP-based products. This article investigates the practical utility of these smaller SPP designs.