Liquid Chromatography: Pharmaceutical Applications (Chapter in Reference Module in Chemistry, Molecular Sciences and Chemical Engineering)

Author(s): D.M. Diehl1, David S. Bell2, Barbara Bojko3
1. Waters Corporation, 2. Restek Corporation, 3. Nicolaus Copernicus University

Published By: Elsevier

Year of Publication: 2018

Link: https://www.sciencedirect.com/science/article/pii/B9780124095472144920

Abstract: Liquid chromatography (LC) has been applied in the pharmaceutical industry almost from the inception of the technique. In this article, the overview of recent advancements in LC, like ultra-high-performance liquid chromatography and superficially porous particle (SPP) technology, which were adopted to analysis of pharmaceuticals can be found. The utilization of liquid chromatography during development and manufacturing stages of small molecule drugs is described. That includes aspects of purification, isolation, identification, and stability, among others. The article also considers application of modern LC strategies to analysis of the currently most emerging group of drugs, biopharmaceuticals. Finally, the LC approaches for metabolomics in drug discovery as well as pharmacometabolomics are discussed.

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The Promise of Metal–Organic Frameworks for Use in Liquid Chromatography

Author: David S. Bell

Restek Corporation

Published By: LCGC North America

Year of Publication: June 2018

Volume, Issue: Volume 36, Issue 6

Link: http://www.chromatographyonline.com/promise-metal-organic-frameworks-use-liquid-chromatography

Abstract:  Metal–organic frameworks (MOFs) are self-assembled combinations of metals and inorganic ligands that result in a relatively young class of highly ordered, porous materials. Because of the number of structural and chemical possibilities, high surface area, controlled pore volume, and thermal properties, MOFs are being applied in a number of fields, including chromatography. Although there has been limited application of MOFs for liquid chromatography (LC), early studies have revealed great promise. In this installment of “Column Watch,” recent investigations toward the application of MOFs specifically for LC are presented and discussed.

Liquid Chromatography’s Complementary Role to Gas Chromatography in Cannabis Testing

Authors: Justin Steimling, Ty Kahler

Restek Corporation

Published By: Supplement to LCGC North America

Year of Publication:  June 2018

Volume, Number: Volume 36, Number s6

Link: http://files.pharmtech.com/alfresco_images/pharma/2018/06/13/f119cb54-ce43-4628-95f8-af1aa07bb6ff/LCGC_NAmerica_June2018Supp.pdf

Abstract: The absence of consensus methods for cannabis testing is a challenging, but refreshing opportunity for analytical chemists in the field because it enables the incorporation of the newest technologies and best practices without the restrictions imposed by legacy approaches that often impede method development in other industries. Liquid chromatography (LC) is proving to be a valuable complementary technique to gas chromatography (GC) in cannabis testing for the analysis of cannabinoids, mycotoxins, and pesticides. The industry is emerging during a time when superficially porous particles (SPPs) and ultrahigh-pressure liquid chromatography (UHPLC) have become market standards. This article discusses the adoption of LC technology and its role in cannabis testing.

Beyond Particle Technology

Author: David S. Bell

Restek Corporation

Published By: Supplement to LCGC North America

Year of Publication: June 2018

Volume, Number: Volume 36, Number s6

Link: http://files.pharmtech.com/alfresco_images/pharma/2018/06/13/f119cb54-ce43-4628-95f8-af1aa07bb6ff/LCGC_NAmerica_June2018Supp.pdf

Abstract: Two of the more significant technologies, sub-2-μm particles and superficially porous particles (SPP), have taken a firm hold on modern liquid chromatography practice. Each of these developments were initially met with both excitement and their share of skepticism. Both emotions drove extensive research and ultimately adoption of the ideas. Today, both technologies are routinely used in many industries around the world, but where do we go from here? This supplement was assembled to provide examples of the ongoing research that is building upon recent particle technology developments.

LC Column Technology: The State of the Art

Authors: Gert Desmet1, Fabrice Gritti2, Xiaoli Wang3, Frank Steiner4, Dave Bell5, Tivadar Farkas6, Mel Euerby7

  1. Vrije Universiteit Brussel, 2. Waters Corporation, 3. Agilent Technologies, 4. Thermo Fisher Scientific, 5. Restek Corporation, 6. Phenomenex, Inc., 7. Shimadzu

Published By: LCGC Europe

Year of Publication: November 2017

Volume, Issue: Volume 30, Issue 11

Link: http://www.chromatographyonline.com/lc-column-technology-state-art 

Abstract: Key opinion leaders in the field discuss the current state of the art in liquid chromatography column technology in an extended special feature celebrating the 30th anniversary edition of LCGC Europe.

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4.5 Minute Analysis of Benzodiazepines in Urine and Whole Blood Using LC/MS/MS and an Ultra Biphenyl Column

Author(s): Amanda Rigdon

Published By: Restek Corporation

Year of Publication: 2011

Link: http://www.restek.com/Technical-Resources/Technical-Library/Clinical-Forensic-Toxicology/cf_an1343

Abstract: Sample throughput for benzodiazepines in urine and whole blood can be increased by adopting this dilute-and-shoot LC/MS/MS method which uses an Ultra Biphenyl HPLC column. Partial validation data are presented in this application note.