Author: Landon Wiest
Published By: Restek Corporation
Year of Publication: 2020
Abstract: When preparing calibration curve standards, minimizing sources of error is vital for obtaining accurate quantitative results. This article shares best practices relating to equipment, chemical interactions, and workflow solutions that will help ensure accurate and precise analytical results.
Cannabicyclol (CBL) is formed through the photodegradation of cannabichromene (CBC). Levels are typically quite low, and the medicinal benefits of CBL are still being researched, but quantifying this compound in cannabis samples is crucial for obtaining a more-complete cannabinoids profile. Restek has just released a new CBL certified reference material (CRM) to further aid labs in the comprehensive characterization of cannabis: www.restek.com/catalog/view/54615
Restek’s new CBL standard is ideal for creating multipoint (5-point minimum suggested) calibration curves for LC analysis. With verified composition and stability, this prepared stock product eliminates the need for in-house standards preparation for greater convenience and lower labor requirements. As a U.S. DEA-exempted formulation, no additional customer permits or licensing are required to purchase within the U.S., and because it’s manufactured and QC tested in Restek’s ISO-accredited labs, this new CBL standard qualifies as a certified reference material (CRM) that satisfies your ISO requirements.
For CBL and other reference standards, Raptor LC columns, sample preparation products, and the expert consultation your cannabis lab needs, turn to www.restek.com/cannabis
Cannabis strains with high levels of cannabidiol (CBD) typically have higher levels of cannabidivarin (CBDV) as well, but accurate quantitation of both compounds for potency and strain ID is a must, especially as interest in using CBDV as an anticonvulsant and anti-nausea treatment continues to rise. Restek now offers a stand-alone CBDV reference standard—in addition to CBD and a host of other compounds—to help labs with the comprehensive analysis of cannabis products.
Restek’s CBDV standard is ideal for creating multipoint (5-point minimum suggested) calibration curves for LC-MS/MS. With verified composition and stability, this prepared stock product eliminates the need for in-house standards preparation for greater convenience and lower labor requirements. As a U.S. DEA-exempted formulation, no additional customer permits or licensing are required to purchase within the U.S., and because it’s manufactured and QC tested in Restek’s ISO-accredited labs, this new CBDV standard qualifies as a certified reference material (CRM) that satisfies your ISO requirements.
For CBDV, CBD, and other cannabis reference standards, along with the expertise and consumables your lab needs, turn to www.restek.com/cannabis
Restek’s support for cannabis-testing labs continues to grow. This latest offering will help you meet the specific cannabis analysis needs of California set forth by the Bureau of Cannabis Control for regulated category I and II residual pesticide reporting—and of other states with similar regulations/programs. Ideal for creating multipoint (5-point minimum suggested) calibration curves for GC- and LC-MS/MS, these six mixes of prepared stock standards also eliminate the need for in-house standards preparation. And, as with all certified reference materials (CRMs) manufactured and QC tested in Restek’s ISO-accredited labs, they will satisfy your ISO requirements.
Order today at www.restek.com/cannabis
Restek’s ever-growing selection of cannabis reference standards has expanded again with a new cannabigerolic acid (CBGA) CRM. This certified reference material (CRM) is U.S. DEA exempt, so there’s no need to purchase costly neat materials, make your own standards, or deal with DEA forms and registrations. Verified in composition and stability, this CBGA standard is ideal for combining with other Restek cannabinoid CRMs for quantitative potency analysis using the Raptor ARC-18 LC column. And like all Restek certified reference materials (CRMs), it is manufactured and QC tested in ISO-accredited labs to satisfy your ISO requirements.
Your CBGA standard is in stock now at www.restek.com/catalog/view/54064 You can also find it, along with the rest of Restek’s cannabis analysis solutions, at www.restek.com/cannabis
Growing concern about the impact of partially hydrogenated oils on human heart health makes accurate data on trans fat content in foods critical for protecting consumers. New reference standards from Restek help you ensure that your lab is generating accurate results. In addition to a derivatization agent, we also offer internal and calibration standards of verified composition and stability. Paired with an Rt-2560 GC column, these new reference standards help ensure accurate determination of trans fat content in foods and edible oils, and they are suitable for AOAC and AOCS methods.
Restek is a long-time partner of pharmaceutical QC labs performing residual solvent analysis, and our support continues with the release of an updated Class 2 Mix A reference standard. This standard has been reformulated to include cumene, which was added to the USP Class 2 list in August 2013, and allows labs to successfully detect and quantify solvent residues in compliance with the latest USP <467> guidelines.
As with our other USP <467> mixes, this standard is prepared with the superior quality and reliability you have come to expect from Restek. It is quantitatively tested to confirm composition and stability, and detailed documentation is provided. In addition, being manufactured and QC-tested in Restek’s ISO-accredited labs means this standard will also help satisfy strict ISO requirements for the use of certified reference materials (CRMs).
Restek is your complete supplier for world-class USP <467> residual solvent analysis. Get the up-to-date reference standards, Rxi®-624Sil MS (G43) and Stabilwax® (G16) GC columns, inlet liners, accessories, and applications you need at
About USP <467> Class 2 Residual Solvents:
The United States Pharmacopeia (USP) General Chapter <467> Residual Solvents is a widely used compendial method intended for identifying and quantifying residual solvents in drug substances, drug products, and excipients. This method identifies acceptable amounts of solvent residues that can be present, and the solvents are summarized by class according to their toxicity. Class 2 compounds are nongenotoxic animal carcinogens, and concentrations of these compounds should be limited. Chromatographic analysis is needed for both the Class 1 and Class 2 residual solvents. This new standard reflects the changes made in USP <467> effective August 2013 and replaces Restek® cat.# 36271.