Author(s): D.M. Diehl1, David S. Bell2, Barbara Bojko3
1. Waters Corporation, 2. Restek Corporation, 3. Nicolaus Copernicus University
Published By: Elsevier
Year of Publication: 2018
Link: https://www.sciencedirect.com/science/article/pii/B9780124095472144920
Abstract: Liquid chromatography (LC) has been applied in the pharmaceutical industry almost from the inception of the technique. In this article, the overview of recent advancements in LC, like ultra-high-performance liquid chromatography and superficially porous particle (SPP) technology, which were adopted to analysis of pharmaceuticals can be found. The utilization of liquid chromatography during development and manufacturing stages of small molecule drugs is described. That includes aspects of purification, isolation, identification, and stability, among others. The article also considers application of modern LC strategies to analysis of the currently most emerging group of drugs, biopharmaceuticals. Finally, the LC approaches for metabolomics in drug discovery as well as pharmacometabolomics are discussed.