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Residual Solvents Class 2 - Mix A (2013 Rev) 0.35-19.4 mg/mL, DMSO, 1 mL/ampul
  1. Residual Solvents Class 2 - Mix A (2013 Rev) 0.35-19.4 mg/mL, DMSO, 1 mL/ampul

Residual Solvents Class 2 - Mix A (2013 Rev) 0.35-19.4 mg/mL, DMSO, 1 mL/ampul

Catalog No. 36012
$59.00
Shipping Note
Reference standards shipped after December 31, 2023, will no longer include paper hard copies of certificates of analysis (CofAs). Access your CofA online at www.restek.com/documentation
Residual Solvents Class 2 - Mix A (2013 Rev) 0.35-19.4 mg/mL, DMSO, 1 mL/ampul

Residual Solvents Class 2 - Mix A (2013 Rev) 0.35-19.4 mg/mL, DMSO, 1 mL/ampul

$59.00

Overview

Features & Benefits
  • Detect and quantify USP <467> Class 2 residual solvents in pharmaceuticals.
  • Reformulated to include cumene, added to USP <467> Class 2 list in August 2013.
  • Quantitatively tested to confirm composition and stability; detailed support documentation provided.
  • Restek is your complete supplier for world-class USP <467> residual solvent analysis: reference standards, Rxi-624Sil MS (G43) and Stabilwax (G16) GC columns, inlet liners, accessories, applications, and more.

Additional USP <467> certified reference materials also available.

Using a large-volume Gas-Tight syringe? Be sure to choose the right liner.

Description

The United States Pharmacopeia (USP) General Chapter <467> Residual Solvents is a widely used compendial method intended for identifying and quantifying residual solvents in drug substances, drug products, and excipients. In an attempt to better mirror the International Conference on Harmonization (ICH) guidelines, the USP has adopted a more comprehensive methodology in residual solvent testing—the current USP30/NF25. The ICH publishes a guideline (Q3C) listing the acceptable amounts of solvent residues that can be present. In the ICH guideline, residual solvents are summarized by class according to their toxicity. Class 1 compounds are carcinogenic compounds that pose a risk to both the consumer and the environment. The use of these solvents is to be avoided, but if they are used, they must be tightly controlled. Class 2 compounds are nongenotoxic animal carcinogens, and concentrations of these compounds should be limited. Chromatographic analysis is needed for both the Class 1 and Class 2 residual solvents.

This mixture reflects the changes made in USP <467> effective August 2013 and replaces Restek cat.# 36271.

Acetonitrile (75-05-8), 2.05 mg/mL
Chlorobenzene (108-90-7), 1.8 mg/mL
Cyclohexane (110-82-7), 19.4 mg/mL
cis-1,2-Dichloroethene (156-59-2), 4.675 mg/mL
trans-1,2-Dichloroethene (156-60-5), 4.675 mg/mL
1,4-Dioxane (123-91-1), 1.9 mg/mL
Ethylbenzene (100-41-4), 1.84 mg/mL
Isopropylbenzene (cumene) (98-82-8), 0.35 mg/mL
Methanol (67-56-1), 15 mg/mL
Methylcyclohexane (108-87-2), 5.9 mg/mL
Methylene chloride (dichloromethane) (75-09-2), 3 mg/mL
Tetrahydrofuran (109-99-9), 3.6 mg/mL
Toluene (108-88-3), 4.45 mg/mL
m-Xylene (108-38-3), 6.51 mg/mL
o-Xylene (95-47-6), 0.98 mg/mL
p-Xylene (106-42-3), 1.52 mg/mL

Specifications

Product Specifications
Catalog No.
36012
Product Name
Residual Solvents Class 2 - Mix A (2013 Rev) 0.35-19.4 mg/mL, DMSO, 1 mL/ampul
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