Combination Run of U.S. EPA Methods 521 and 522, Nitrosamines and 1,4-Dioxane, on Rxi-5Sil-MS by CSR-LVSI

GC_EV1334

	Peaks	Conc. (ng/mL)
1.	Tetrahydrofuran-d8 (IS)	100
2.	Tetrahydrofuran	50
3.	1,4-Dioxane-d8 (SS)	200
4.	1,4-Dioxane	50
5.	N-Nitrosodimethylamine-d6 (SS)	20
6.	N-Nitrosodimethylamine	2.5
7.	N-Nitrosomethylethylamine	5.0

	Peaks	Conc. (ng/mL)
8.	N-Nitrosodiethylamine	5.0
9.	N-Nitrosodi-n-propylamine-d14 (IS)	10
10.	N-Nitrosopyrrolidine	5.0
11.	N-Nitrosodi-n-propylamine	5.0
12.	N-Nitrosomorpholine	2.5
13.	N-Nitrosopiperidine	5.0
14.	N-Nitrosodi-n-butylamine	5.0

Injection
Column	Rxi-5Sil MS, 30 m, 0.25 mm ID, 1.00 µm (cat.# 13653)
	using Rxi guard column 10 m, 0.53 mm ID (cat.# 10073)
	with SGE µ-union
Standard/Sample	N-Nitrosodimethylamine-d6 (cat.# 33910)
	1,4-Dioxane-d8 (cat.# 30614)
	N-Nitrosodi-n-propylamine-d14 (cat.# 33911)
	Tetrahydrofuran-d8 (cat.# 30112)
	Nitrosamine calibration mix, Method 521 (cat.# 31898)
	Appendix IX mix #1, revised (cat.# 32459)
Diluent:	Dichloromethane
Inj. Vol.:	50 µL splitless (hold 1.5 min)
Liner:	Custom Premium single taper 4 mm ID liner with 15 mg quartz wool
Inj. Temp.:	275 °C
Purge Flow:	100 mL/min
Oven
Oven Temp.:	35 °C (hold 1.5 min) to 50 °C at 50 °C/min (hold 7.1 min) to 320 °C at 11.12 °C/min (hold 1.5 min)
Carrier Gas	He, flow program
Flow Program:	5.08 mL/min (hold 8.9 min) to 2.0 mL/min at 1.0 mL/min/min

Detector

MS

Mode:

SIM

SIM Program:

Group	Start Time (min)	Ion(s) (m/z)	Dwell (ms)
1	9.9	42, 46, 71, 72, 78, 80	20
2	10.5	58, 62, 64, 88, 96	20
3	11.2	42, 43, 46, 48, 74, 80	20
4	12	43, 56, 88, 102	30
5	15.5	58, 68, 70, 78, 86, 100, 116, 130, 144	20
6	17.4	84, 99, 114, 116, 141, 158	20

Transfer Line Temp.:

320 °C

Analyzer Type:

Quadrupole

Source Temp.:

230 °C

Quad Temp.:

150 °C

Solvent Delay Time:

9.9 min

Tune Type:

BFB

Ionization Mode:

EI

Instrument

Agilent 7890A GC & 5975C MSD

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