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Organic Volatile Impurities on Rtx-5 (Rtx-G27)

GC_PH00260
Peaks
1.Ethylene oxide
2.Methanol
3.Ethanol
4.Diethyl ether
5.1,1-Dichloroethene
6.Acetone
7.Isopropanol
8.Acetonitrile
9.Methylene chloride
10.n-Hexane
11.n-Propanol
12.Methyl ethyl ketone
Peaks
13.Ethyl acetate
14.Tetrahydrofuran
15.Chloroform
16.1,1,1-Trichloroethane
17.Carbon tetrachloride
18.Benzene
19.1,2-Dichloroethane
20.Heptane
21.Trichloroethylene
22.n-Butanol
23.1,4-Dioxane
24.Pyridine
25.Toluene
ColumnRtx-5 w/5m Integra-Guard Column (Rtx-G27), 30 m, 0.53 mm ID, 5.00 µm (cat.# 10279-126)
Standard/SampleHeadspace injection of common solvents for pharmaceutical processing. Prepared to equal about 500 ppm in the bulk pharmaceutical. Samples shaken and heated at 90 °C for 15 minutes, 1 mL headspace injection.
Injection
Inj. Vol.:1,000 µL headspace-syringe split (split ratio 2:1)
Inj. Temp.:220 °C
Oven
Oven Temp.:35 °C (hold 10 min) to 100 °C at 5 °C/min to 240 °C at 25 °C/min (hold 5 min)
Carrier GasHe, constant pressure
Linear Velocity:35 cm/sec @ 35 °C
DetectorFID @ 240 °C
NotesFID sensitivity: 1.05 x 10-11 AFS
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