Potential Genotoxic Impurities (PGIs) on Rtx-200

GC_PH01076

	Peaks
1.	1-Chloropropane
2.	Bromoethane
3.	2-Chloropropane
4.	1-Bromopropane
5.	2-Bromopropane
6.	1-Bromobutane
7.	Dimethyl sulfate (DMS)
8.	Methyl methanesulfonate (MMS)
9.	Ethyl methanesulfonate (EMS)
10.	Isopropyl methanesulfonate (iPMS)
11.	Diethyl sulfate (DES)

	Peaks
12.	di-Isopropyl sulfate (DPS)
13.	di-n-Propyl sulfate (DNS)
14.	Dibutyl sulfate (DBS)
15.	Methylbenzene sulfonate (MBS)
16.	Ethylbenzene sulfonate (EBS)
17.	Methyl toluenesulfonate (MTS)
18.	Ethyl toluenesulfonate (ETS)
19.	n-Butyl benzenesulfonate (nBBS)
20.	n-Propyl toluenesulfonate (nPTS)
21.	Isopropyl toluenesulfonate (iPTS)
22.	n-Butyl toluenesulfonate (nBTS)

* ortho isomer of ethyl toluenesulfonate

Standard/Sample
Column	Rtx-200, 30 m, 0.25 mm ID, 1.0 µm (cat.# 15053)
Diluent:	90:10 acetonitrile:water
Conc.:	100 µg/mL
Injection
Inj. Vol.:	1 µL split (split ratio 10:1)
Liner:	4mm Gooseneck Splitless w/Wool (cat.# 22405)
Inj. Temp.:	220 °C
Oven
Oven Temp.:	40 °C (hold 8.3 min) to 70 °C at 70 °C/min to 115 °C at 40 °C/min to 250 °C at 30 °C/min to 300 °C at 15 °C/min (hold 3 min)
Carrier Gas	He, constant flow
Flow Rate:	1 mL/min

Detector	MS
Mode:	Scan
Transfer Line Temp.:	280 °C
Ionization Mode:	EI
Scan Range:	20-250 amu

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